The study consists of two parts. In the first part, healthy subjects will be administered the tablets with different THC and CBD ratios. The first part of the research will show whether the adverse effects of THC, such as getting high or feeling anxious, can be reduced by administering CBD simultaneously. According to Groeneveld, the scientific literature has so far provided conflicting results about this: “To be honest, I do not expect much from CBD alone as a treatment for neuropathic pain. From a pharmacological point of view, it is likely that THC affects pain, but this is less the case for CBD. CBD could have an effect on inflammation, but there is no reason to use CBD as a treatment for inflammatory pain. We already have Ibuprofen for that. It will only become interesting if the adverse effects of THC, such as feelings of anxiety, can be alleviated by administering CBD at the same time. “
THC (9-tetrahydrocannabinol) and CBD (cannabidiol) are the two most studied active ingredients of the cannabis plant. THC is known for its analgesic effect, but it also causes psychoactive side effects. CBD could lead to pain-relieving effects through other mechanisms. It is believed that CBD may also influence the psychotropic effects of THC by modulating THC binding to the CB1 receptor. However, it is still unclear what the ideal ratio of THC to CBD would be to take advantage of the CB1 modulating effects of CBD while preserving the positive effects of THC on pain. In addition, it is still unclear whether the analgesic effects that some patients experience as a result of CBD use are due to a pharmacological action of CBD, or simply because CBD prevents the metabolism of concomitantly used pain killers. The latter will also be investigated in these studies.
The researchers will very accurately measure the pharmacodynamics and pharmacokinetics of THC and CBD, the effects of both substances on pain and brain function and how the substances behave in the human body.
The research intends to lead to a specific recommendation of an optimal delta-9-tetrahydrocannabinol (THC) – cannabidiol (CBD) dosage for the treatment of neuropathic pain in a particular subgroup of patients. In addition, it contributes to evidence for the effectiveness of medicinal cannabis. Bedrocan’s raw materials will be used for the production of the research material.
The Dutch government is supporting research into the use of medicinal cannabis in the treatment of neuropathic pain with € 1.9 million. The grant has been awarded to a joint project of the Centre for Human Drug Research (CHDR), a Dutch independent institute that specializes in clinical drug research, and the Leiden University Medical Center (LUMC). Neurologist Geert Jan Groeneveld (CSO / CMO at CHDR and professor of Clinical Neuropharmacology at the LUMC) and Albert Dahan (professor of Anesthesiology at the LUMC) will conduct the research.
Search for the ideal ratio between THC and CBD
Subsequently, the participants in a crossover study will receive placebo for five weeks, and after a wash-out period, they will receive five weeks of cannabinoid treatment or vice versa. Pain will be measured in each treatment period. Groeneveld: “In patients with clear pain relief, we want to further investigate whether there is a correlation between their variables, such as sleeping problems, anxiety or peripheral nerve damage, and the response to treatment with THC.”
The effects on pain in patients will not be investigated until the second part of the study, after the results of the first study are known. This will provide information on which THC:CBD ratio works best. The second part of the study will take place among a diverse group of 200 patients with different neuropathic pain conditions. Groeneveld: “We are going to phenotype this group very well in advance. This means that we want to know exactly how the neuropathic pain manifests itself specifically in this group. Do patients have demonstrable nerve damage, do they have a personality disorder, are they depressed, or do they have sleep disorders? All these are variables that we are going to map.”
Studies also suggest some efficacy for cancer-related pain, migraines, and fibromyalgia, and other pain conditions. 3 However, how different species, routes of administration, and doses differ in their effect is less clear, and more research is needed.
The key to using medical cannabis for pain is two-fold. For starters, a personalized approach is needed. Each person is different, and many adjustments may be needed to zero in on the dose that controls pain with minimal side effects. It’s also important to start on a low dose of THC and CBD.
Where does this leave chronic pain patients interested in trying medical cannabis? Regardless of the strain or form of cannabis, the key is the amount of THC and CBD in the final product, according to Dr. Bearman.
Before elaborating on the many benefits and uses of the ratio, it’s important to highlight that a high can be used and altered in many different ways to your advantage. For example, pairing coffee or an energizing tea with a 1:1 tincture would offer an energizing and productive high, giving the mind a chance to focus and accomplish tasks. On the other hand, if you’re looking for a much more relaxed feeling, you can pair your 1:1 product with a chamomile tea.
At a higher dose, the 1:1 ratio is very effective for fighting acute and chronic pain. Recall that THC calms your nervous system and CBD relaxes your immune system. Many patients with overall body aches or localized nerve pain have found the 1:1 ratio really helps them manage pain on a daily basis. CBD is also known to regulate serotonin levels, which is linked to anxiety, stress, and mood.
Kush Queen Awaken Bath Bomb – Cannabis bath bombs are a great way to use topicals. Since you’re in the bath, even coverage is pretty much a guarantee. The Awaken Bath Bomb is a great way to get rid of aches and pains, and for the body and mind to completely relax. Skin is the biggest organ with most of our CB1 and CB2 receptors.
AC/DC Heavy Hitters Cartridge – AC/DC is one of the few prominent CBD strains out there, and coming across a true 1:1 strain is difficult. Luckily, Heavy Hitters has made a cartridge that stays true to the strain’s profile. Take a few hits of this cartridge and you will experience what a 1:1 is really like.
The entourage effect is when cannabinoids and terpenes other than THC work synergistically with THC. For the 1:1 ratio, our entourage effect is produced from THC and CBD working together.