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Acute and subacute bronchial effects of oral cannabinoids
The bronchodilating activity of oral cannabinoids was evaluated in three double-blind experiments that involved the study of dose-response and interactive relationships and the potential development of tolerance. Data indicated that delta 8-tetrahydrocannabinol (delta 8-THC), cannabinol (CBN), and cannabidiol (CBD) in maximal doses of 75 mg, 1200 mg, and 1200 mg, respectively, did not induce significant dose-related physiologic effects in experienced marijuana smokers. delta 8-THC (75 mg) was, however, associated with bronchodilation, tachycardia, and peak highs less than that after delta 9-tetrahydrocannabinol (delta 9-THC). The combinations of CBN and CBD with low-dose delta 9-THC (5 mg) did not induce significant bronchodilation but did exert interactive effects on heart rate and “high.” A 20-day study of daily delta 9-THC (20 mg), CBN (600 mg), and CBD (1200 mg) did not indicate tolerance or reverse tolerance to any drug. We conclude that delta 9-THC and, to a lesser extent, delta 8-THC, have acute bronchodilator activity but that CBN, CBD, and their combinations do not provide effective bronchodilation. The daily use of delta 9-THC was not associated with clinical tolerance.
Alozie SO, Martin BR, Harris LS, Dewey WL. Alozie SO, et al. Pharmacol Biochem Behav. 1980 Feb;12(2):217-21. doi: 10.1016/0091-3057(80)90359-7. Pharmacol Biochem Behav. 1980. PMID: 6246544
Järbe TU, Henriksson BG, Ohlin GC. Järbe TU, et al. Arch Int Pharmacodyn Ther. 1977 Jul;228(1):68-72. Arch Int Pharmacodyn Ther. 1977. PMID: 921403
Molnar A, Fu S, Lewis J, Allsop DJ, Copeland J. Molnar A, et al. Forensic Sci Int. 2014 May;238:113-9. doi: 10.1016/j.forsciint.2014.03.004. Epub 2014 Mar 12. Forensic Sci Int. 2014. PMID: 24699310 Clinical Trial.
McGilveray IJ. McGilveray IJ. Pain Res Manag. 2005 Autumn;10 Suppl A:15A-22A. doi: 10.1155/2005/242516. Pain Res Manag. 2005. PMID: 16237477 Review.
Stout SM, Cimino NM. Stout SM, et al. Drug Metab Rev. 2014 Feb;46(1):86-95. doi: 10.3109/03602532.2013.849268. Epub 2013 Oct 25. Drug Metab Rev. 2014. PMID: 24160757 Review.
Laudanski K, Wain J. Laudanski K, et al. J Clin Med. 2022 Jan 22;11(3):558. doi: 10.3390/jcm11030558. J Clin Med. 2022. PMID: 35160010 Free PMC article. Review.
Corroon J. Corroon J. Cannabis Cannabinoid Res. 2021 Oct;6(5):366-371. doi: 10.1089/can.2021.0006. Epub 2021 Aug 31. Cannabis Cannabinoid Res. 2021. PMID: 34468204 Review.
Kicman A, Toczek M. Kicman A, et al. Int J Mol Sci. 2020 Sep 14;21(18):6740. doi: 10.3390/ijms21186740. Int J Mol Sci. 2020. PMID: 32937917 Free PMC article. Review.
Merrick J, Lane B, Sebree T, Yaksh T, O’Neill C, Banks SL. Merrick J, et al. Cannabis Cannabinoid Res. 2016 Apr 1;1(1):102-112. doi: 10.1089/can.2015.0004. eCollection 2016. Cannabis Cannabinoid Res. 2016. PMID: 28861485 Free PMC article.
Vergara D, Bidwell LC, Gaudino R, Torres A, Du G, Ruthenburg TC, deCesare K, Land DP, Hutchison KE, Kane NC. Vergara D, et al. Sci Rep. 2017 Apr 19;7:46528. doi: 10.1038/srep46528. Sci Rep. 2017. PMID: 28422145 Free PMC article.