An ET-specific medication would impact millions of people around the world who have this life-altering condition but who don’t respond to the medications that are currently available. An ET-specific medication would be a life-changer for millions of men, women and children today and for generations to come.
In this study, Dr. Handforth aimed to show CBD can suppress tremor in animal models. If successful, it would offer justification for further study of CBD in humans. First, the study had to determine what effects CBD would have on mice impacted with harmaline–induced tremor. Then, if reduced, the team had to discover how CBD suppressed the tremor.
Cannabidiol Anti-Tremor Action & Mechanisms – Conclusion
The U.S. Food and Drug Administration (FDA) has not approved cannabis as a treatment for any medical condition. However, the chemical components in cannabis are being studied. It is well known that certain chemicals in cannabis activate specific receptors throughout the body and these chemicals may be useful in treating neurological conditions, like ET. In this study, Dr. Handforth is looking at a specific chemical called Cannabidiol. Cannabidiol (CBD) is one of at least 113 active chemicals (also known as cannabinoids) identified in cannabis. However, CBD does not produce any intoxicating effects or alteration in mood. For years it was thought to be a benign and unimportant part of the plant. Now it is being investigated as a possible treatment option for ET.
Dr. Handforth is the lead researcher of an upcoming IETF funded study that will explore the effects of a particular cannabinoid known as “CBD” (cannabidiol) on essential tremor. Unlike the well-known cannabinoid “THC” (tetrahydrocannabinol), which has mind- and mood-altering effects, CBD does not alter the mind, the emotions, or one’s judgment. Although its long-term safety remains to be thoroughly studied, CBD has already shown some promising initial results in the treatment of epilepsy, pain, anxiety, and other disorders. Dr. Handforth and his team will try to find out whether CBD can suppress essential tremor in an animal model. And if it does, he will take the next step and try to understand how it works.
Principle Investigator: Adrian Handforth, MD
Patients may also make lifestyle changes in physical, speech, and occupational therapy. Seeing licensed professionals can help people improve their muscle control through training and exercises. In addition, removing stimulants like caffeine or tremor-inducing medications can help as well.
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Action tremors are a bit more complicated. Action tremors — you guessed it — occur when the individual or affected body part is in motion. There are several subtypes of action tremors. According to the National Institute of Health, there are 5 different action tremor subtypes:
Here’s what it boils down to:
It’s really important to understand what is causing your tremors and what your treatment options are. Cannabis as medicine is exploding in popularity in places like the United States where it is used to treat seizures, chronic pain, and neurological disorders like Post Traumatic Stress. It’s important to stay proactive about your health and learn as much as possible through trained professionals about your specific conditions.
Doctors will evaluate tremors based on neurological and physical examination. Doctors will examine where the tremor occurs in the body when it occurs (acting or resting), and the frequency and amplitude of the tremors. Those with Parkinson’s commonly experience tremors. In a blog post on the Cleveland Clinic’s website, Hubert Fernandez, MD, Director of the Cleveland Clinic’s Center for Neurological Restoration, states, “ Parkinson’s motor problems are quickly recognizable. The tremors — rhythmic movement of lips, chin, hands, and legs; rigidity; stiffness and slowness are hallmark signs. Balance and gait problems are also common. But, Parkinson’s symptoms start long before these problems emerge. As a progressive disease, Parkinson’s destroys the brain’s nerves from the bottom up.” He also states that “only a neurologist can diagnose Parkinson’s” and encourages those who may think they have Parkinson’s to get a neurologist involved earlier.
Tremors can be classified in two different ways. A resting tremor is when shaking occurs even when a person or muscle is at rest. Parkinson’s patients commonly experience these — their hands will shake even if they are laying down and their hands are resting on their lap. Resting tremors can occur in any area of the body but are most commonly found in the hands and fingers.
Tremors are involuntary and can impact the legs, hands, arms, head, face, body, and voice. Generally, tremors are caused by neurological dysfunction in the brain affecting how muscles are controlled. Conditions that destroy or degrade the brain like stroke or a brain injury can cause tremors.