Can I Give My Dog Prednisone And CBD Oil

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Prednisone for dogs – a standard solution used by veterinarians everywhere to prevent dogs from getting sick. Read to know more here. This article will show you what to give your dog instead of Prednisone for inflammation-related conditions, such as allergies and skin problems. Explore natural alternatives to Prednisone. Prednisone may be used on dogs to help relieve shock or asthma, but with caution as the US Food & Drug Administration (FDA) hasn't approved it yet for vet use.

Prednisone for Dogs

No matter who you are, your dog quickly becomes a treasured member of the family, and like any family member, they will get sick at some point. And, just like any other member of the family, you will go above and beyond to help them get better. One treatment for this is prednisone, a standard solution used by veterinarians everywhere. However, is it all it’s cracked up to be, or is there a better way?

What is Prednisone?

Prednisone is a steroid used to treat inflammation in your dog while also assisting its immune system. It is stronger than the naturally released cortisol, and it is converted to prednisolone in your dog’s liver . If your dog has a weak liver function , vets may skip prednisone altogether, and instead prescribe prednisolone to save on conversion.

As it can treat a wide range of diseases and conditions, prednisone is a popular option for ensuring your dog gets back to its silly and energetic self. However, as with many treatments out there, it does come with side effects that you may want to avoid.

Why is Prednisone Bad for Dogs?

These side effects can range from increased thirst to lethargy, and while these may not be considered too extreme, they can still have adverse effects on your dog’s health . This is especially true when side effects compounds. For example, increased thirst can lead to more frequent urination, but as another side effect of prednisone is infrequent urination in dogs, it could cause an infection .

Other side effects include increased appetite , which can cause discomfort, and it can also take longer for wounds to hea l, which is especially concerning if your dog gets sick or injured easily during his or her routine walk.

Furthermore, vomiting and diarrhea are other possible side effects, and this can happen even if your dog does not overeat during mealtime.

There is also a chance that it could affect their overall behavior, becoming more aggressive. After all, no one wants their dog to snap, bark, or growl at guests, strangers, or even their family members, and if you have other pets and small children, this could be a cause for concern.

There are also long-term risks associated with prednisone prescriptions and treatment, primarily if you use the steroid for an extended time. Conditions such as Addison’s disease, Cushing’s disease, diabetes, heart problems, or even heart attacks are potentially fatal issues, so it’s worth understanding alternatives to using prednisone to treat your dog’s health problems.

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Why Should You Use CBD Instead?

Using CBD for treatment is a superb and all-natural alternative to pharmaceutical medications. These solutions, which you can find on the Dop Dog store, can get your dog back to perfect health just as quickly, and without the same issues that you might encounter with prednisone.

Pros

It’s non-toxic

As an all-natural ingredient, you can trust that CBD treatment is entirely non-toxic . This helps reduce the risk of side-effects and will focus only on treating whatever issues your dog may suffer from.

It’s more affordable.

If you thought medicine was expensive for humans, medicine for dogs, or any pet, is on a whole other level. As a dog owner, you know you will do anything it takes to ensure your dog gets back to its usual self, so you are willing to spend whatever you need to make sure that happens.

CBD treatments are more affordable than other medical treatments , which is excellent news for anyone on a budget or looking for a natural and affordable solution. Plus, with the extra money you save on medicine, you can start planning your next doggy-and-you vacation. We hear the Rockies is terrific this time of year.

It treats many common problems.

From cancer pain to anxiety, CBD can treat a range of issues your dog might encounter. As it is all-natural, there is no need to worry about extreme side effects. It can also fight off potential cancer cells, reduce aggressive behavior, ease anxiety , and help with arthritis. This ensures that your dog will bound around the park for many, many years to come.

Your dog won’t get high off it.

There is zero THC , the psychoactive component of cannabis; you don’t need to worry about your dog getting high and eating all of the snacks in the cupboard.

Cons

While CBD can be useful for treating your dog for a range of problems, illnesses, and diseases, it is not entirely perfect . As with anything you allow your dog to ingest, you must understand the cons as well as the pros.

It can still make them lethargic.

As your dog will not be used to CBD as medication, there is a chance that it may become less energetic when you start using it . Because of this, it’s worth starting the treatment in small doses to get them used to the effects.

You can still encounter problems if you give them too much.

Likewise, giving your dog too much CBD treatment can have effects on your pooch. You must follow the application guidelines to prevent this from happening.

Even with these cons, there are still more pros for using CBD as a treatment for your dog . With this in mind, it’s worth considering your options the next time your dog appears to be suffering from anxiety or more significant problems to see whether CBD is the solution.

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Doggy Treats

If your dog is sick or ill and you want an all-natural remedy to get them back on their feet, so you can start going on adventures again, then take the time to consider a CBD rather than prednisone. For all your doggy’s CBD needs, don’t forget to check out the Dope Dog store , as well as embrace the wealth of detailed information on this blog!

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Prednisone Alternatives For Dog: What to Give Your Pet Instead?

Steroids are an important class of medication that have been used to treat human conditions for decades. This class of drugs proves to be just as effective in handling veterinary allergies and inflammatory diseases.

Steroids, such as Prednisone, are employed to alleviate pet allergies and treat asthma-like symptoms, among other conditions.

However, despite its usefulness, Prednisone is not intended for long-term use. Prednisone therapy requires a list of alternatives ready to prevent Steroid addiction.

What is Prednisone?

Prednisone is an oral steroid used to treat autoimmune and inflammatory conditions. It’s a glucocorticoid that diminishes the effects of the immune system by inhibiting the migration of polymorphonuclear leukocytes and reversing increased capillary permeability that is indicative of an inflammatory process.

Prednisone is used in humans and the veterinary population to treat asthma, gout, COPD, Meniere’s disease, lupus, shingles, hives, allergies, and even migraine and cluster headaches. Its immunosuppressive activity may be exercised in organ transplantation, preventing graft rejection.

The medication has also been employed as an antitumor drug and adjunct to cancer therapy. Prednisone is said to manage hypercalcemia caused by cancer activity.

Prednisone may be used to prevent heart failures in patients with renal insufficiency and high blood pressure.

Prednisone is synthetic, FDA-approved, and has a delayed release pattern.

Can Dogs Take Prednisone?

Glucocorticoids are the most common steroids used to treat canine inflammatory disorders and CBD is commonly used to treat allergies on dogs.

When treating a dog with a steroid, it’s crucial to keep the duration of its use in mind. Prednisone may be administered systematically (orally), topically, or by infusion. In any case, the steroid should only be used for short periods to prevent dependence and side effects.

The safest way to take Prednisone to your dog is to apply it topically, using a patch, gel, or cream. Prednisone eye drops may also be used to treat itchy, red eyes associated with an allergy. Long-term use of Prednisone is not advised.

Prednisone for Dogs Dosage

The prednisone dosage depends on the condition it is to be used to treat. It also depends on the severity of the inflammation or allergy and the use of other veterinary medications. Generally speaking, a low dose of Prednisone is needed for anti-inflammatory actions, while a much higher amount is required to suppress the immune system but is a lot more difficult to wean off.

The dosage range for anti-inflammatory and immunosuppressive action is 0.5-1.0mg/lbs (1) (2). For a dog weighing 50 pounds with a mild rash, administer 25mg of Prednisone once a day for three days, then taper the medication by adjusting the dose to once in two days before finally ceasing the medication.

However, if it is used as an immunosuppressive agent following surgery, you may use 50mg of prednisone for a similar duration.

Prednisone dosage should not be extrapolated to Prednisolone because the former undergoes metabolism by the liver, called the first-pass effect.

Side Effects of Prednisone for Dogs

The side effects of prednisone in dogs may be divided into short-term and long-term effects. The long-term effects remain even after the medication is no longer in use.

Short term effects of Prednisone:

  1. Frequent urination and thirst: Prednisone is a drug that influences the production of cortisol by the adrenal glands positioned on the kidneys. These glands are also responsible for the sensation of thirst and water balance. Stimulation of these glands will cause an increase in thirst, which will then spur frequent urination.
  2. Increased appetite and weight gain: cortisol stimulates the metabolism of fats and carbohydrates, releasing stored energy for your cells to boost your activity. However, your brain receives a signal to increase food intake leading to weight gain.
  3. Slower wound healing: when a dog’s skin is cut, the blood vessels in that area immediately constrict to reduce the amount of blood lost. The blood loss triggers the immune system, which sends leucocytes to the injury site. Prednisone prevents the migration of leucocytes involved in wound healing and inflammation.
  4. Higher risk of infection: while the immune system remains compromised, foreign or opportunistic pathogens that make up the microbiome may increase and initiate an infection.

Long term effects of Prednisone:

  1. Diabetes: long term administration of high doses of prednisone is known to cause hyperglycemia in dogs. The elevated blood sugar levels persist one week to four months after discontinuation of prednisone (3). Studies suggest that prednisone overuse may irreversibly damage the pancreatic cells responsible for glucose metabolism.
  2. Bone demineralization: cortisol causes calcium to be absorbed from the bone into the blood, a process called demineralization of bone. This demineralization is peculiar to the lumbar spine. A dog population was treated with 2mg/kg of Prednisone for 30 days and witnessed a 14% loss in bone mass (4).
  3. Behavioral changes: dogs treated with Prednisolone and its analog display more aggressive tendencies, especially in the presence of food. They are also more restless and more prone to barking than dogs being treated with other classes of medications. Prednisone use is also associated with aversiveness and reduced confidence in canines (5).
  4. Adrenal insufficiency: overstimulation of the adrenal glands, caused by overuse of corticosteroids, will reduce the production of cortisol. This may be likened to dependence. In this case, once Prednisone is ceased, an adrenal crisis may occur (6).

Alternatives to Give Your Dog Instead of Prednisone

Yucca Shidigera

Yucca shidigera is a Native American plant grown for ornamental purposes. Aside from its aesthetical uses, it may relieve pain, reduce inflammation, improve digestion and circulation. It is also rumored to treat high blood pressure, diabetes, arthritis, amongst others.

Turmeric

Turmeric is said to have anti-oxidant, anti-inflammatory, and healing properties in humans and dogs. The spice is also safe for coloring in both human and dog food. The question of its anti-inflammatory potency in dog food is directly linked to its dosage.

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Dog treats typically contain a sparse amount of turmeric as a flavor enhancer or even to improve the color of the treat. Still, these dosages are too little to sprout any anti-inflammatory properties.

Unfortunately, no studies have been performed using higher doses of turmeric, so it’s difficult to ascertain whether turmeric will indeed reduce inflammation in dogs.

CBD Oil

CBD oil is a natural extract obtained from Cannabis sativa. It only contains trace amounts of THC in its natural form, so you won’t get high off of it. A good quality CBD oil for your dog has the potential to relieve itching, inflammation, pain, and restlessness. In a recent study, CBD was administered to a canine population. The scientists observed that the dogs experienced a slight upregulation of IL-10, an anti-inflammatory cytokine, and a more pronounced downregulation of IL-6 and 1L-8, the pro-inflammatory cytokines (7).

Thus we may infer that CBD can modulate the immune system. This may become a novel therapy for allergies and immune reactions in pets.

CBD and Prednisolone: Can They Be Taken Together?

Both Prednisone and CBD are potentially effective options for pet allergies. However, concomitant use of these medications is not advised. Prednisone inhibits cytochrome P450, just like CBD.

This means that CBD may delay the systemic clearance of Prednisone. The increased serum Prednisone levels increase the risk of long-term side effects, even with short-term use.

However, since pulse therapy is advised with corticosteroids, CBD may fill the spaces. When administering CBD and Prednisone, ensure that you cease one treatment before initiating the other. Certain types of drugs and CBD shouldn’t be mixed or administered within the same day, and Prednisone is one of them.

Conclusion

Prednisone is an oral steroid used to combat inflammation and allergic reactions in dogs. While it can be a decent source of relief when used short-term at appropriate doses, long-term use or giving Prednisone without prior consultation with a veterinarian can do more harm than good.

If you’re looking for natural alternatives to Prednisone for your dog, try natural health supplements like turmeric or CBD oil. CBD is the most versatile and best-researched anti-inflammatory compound of all alternative options mentioned in this article. It’s also the only compound that regulates the functioning of your dog’s endocannabinoid system — which is its first line of defense against environmental stressors.

With a properly working endocannabinoid network, your dog’s immune system may return to balance, bringing desired results in a longer period — but with a better safety profile.

Sources:

  1. Sauerbrey, M. L., Mullins, M. N., Bannink, E. O., Van Dorp, T. E., Kaneene, J. B., & Obradovich, J. E. (2007). Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005). Journal of the American Veterinary Medical Association, 230(12), 1866–1869. [1]
  2. Weinfurter, M. (2021). Prednisone for Dogs: Side Effects, Dosage, And Alternatives. Relievet. Retrieved from: https://www.relievet.com/blogs/tips/prednisone-for-dogs-side-effects-dosage-and-alternatives
  3. Zeng, Y., Ricordi, C., Lendoire, J., Carroll, P. B., Alejandro, R., Bereiter, D. R., Tzakis, A., & Starzl, T. E. (1993). The effect of prednisone on pancreatic islet autografts in dogs. Surgery, 113(1), 98–102.
  4. Costa, L. A., Lopes, B. F., Lanis, A. B., De Oliveira, D. C., Giannotti, J. G., & Costa, F. S. (2010). Bone demineralization in the lumbar spine of dogs submitted to prednisone therapy. Journal of veterinary pharmacology and therapeutics, 33(6), 583–586.[2]
  5. Notari, L., Burman, O., & Mills, D. (2015). Behavioural changes in dogs treated with corticosteroids. Physiology & behavior, 151, 609–616. [3]
  6. Broersen, L. H., Pereira, A. M., Jørgensen, J. O., & Dekkers, O. M. (2015). Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis. The Journal of clinical endocrinology and metabolism, 100(6), 2171–2180. [4]
  7. Gugliandolo, E., Licata, P., Peritore, A. F., Siracusa, R., D’Amico, R., Cordaro, M., Fusco, R., Impellizzeri, D., Di Paola, R., Cuzzocrea, S., Crupi, R., & Interlandi, C. D. (2021). Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood. Veterinary sciences, 8(9), 185. [5]
Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

Natural Alternatives to Prednisone for Dogs – August 2022

Prednisone is a corticosteroid used in alleviating symptoms of skin conditions, breathing disorders, arthritis, auto-immune and allergic reactions like hives (13 ) . It suppresses the immune system and inhibits the release of inflammation-causing substances in the body.

Patients’ immune response to Prednisone is positive. It treats auto-immune diseases like ulcerative colitis (inflammatory bowel disease), lupus, and psoriasis.

This corticosteroid also treats central nervous system disorders and hormonal disorders such as Addison’s disease, a rare disorder where the sufferer’s adrenal gland is unable to produce ample amounts of cortisol and aldosterone hormones (14 ) .

Prednisone vs. Prednisolone

Prednisone and prednisolone are both synthetic glucocorticoids (steroid hormones). They can treat the same auto-immune, skin, central nervous system, and hormonal conditions. However, Prednisone still needs to be converted by liver enzymes before it can take effect (15 ) .

Doctors are more likely to prescribe prednisolone to patients who have severe liver diseases or cats as they lack the enzyme needed to break prednisone to prednisolone.

Can Prednisone be Used on Dogs?

Prednisone may be used on dogs but must be administered with caution (16 ) .

It is often used to treat Addison’s disease by supplementing dogs with glucocorticoids that their own body is unable to produce.

Prednisone can also treat dogs for the following conditions (17 ) :

  • Asthma
  • Some cancer forms
  • High blood calcium levels (hypercalcemia)
  • Central nervous system disorders
  • Skin disease
  • Arthritis
  • Shock

An article by Dr. Tammy Hunter, DVM and Dr. Ernest Ward, DVM reveals that even if Prednisone and Prednisolone are synthetic or human-made corticosteroids, they are more potent than those that are naturally found in the body. Their effects last longer, too (18 ) .

Dogs on Prednisone should be monitored carefully for side effects. According to Hunter and Ward, the benefits outweigh the risks when using Prednisone on pets (19 ) .

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Few side effects will occur when the medication is used correctly.

Similar to many drugs in veterinary medicine, despite Prednisone’s benefits, its use in animals has not been approved by the U.S. Food and Drug Administration (FDA) (20 ) .

Prednisone Dosage for Dogs

If Prednisone is administered for its anti-inflammatory effects, the standard dosage for Prednisone in dogs is 0.5mg per kilogram. If it is used to treat immune system disorders in dogs, the dosage is 1mg per kilogram (21 ) .

When it comes to dosing Prednisone, use as much as is required to treat the symptoms but as little as possible to reduce the chances of the dog experiencing severe side effects (22 ) .

As soon as the dog’s condition improves, the slow tapering of the pet off Prednisone is suggested (23 ) .

According to Dr. Rania Gollakner, BS, DVM, in about 1 to 2 hours, Prednisone should take effect, and significant improvements in the dog should follow (24 ) .

Best combined with pet food, Prednisone comes in tablet, injectable, or liquid form (25 ) .

Dr. Barbara Forney recommends that Prednisone be given to dogs once daily, preferably in the morning (26 ) .

Side Effects of Prednisone on Dogs

Potential short-term side effects of Prednisone on dogs, especially on those who are taking it for its immunosuppressive properties are as follows (27 ) :

  • Increased thirst
  • Excessive urination
  • Increased appetite

When Prednisone is given at higher doses or for long periods of time, more severe and long-term side effects may be observed (28 ) .

  • Increased risk of infection
  • Altered behavior including aggression
  • Inhibited growth especially in young dogs
  • Development or worsening of diabetes
  • Cushing’s disease
  • Vomiting
  • Diarrhea
  • Ulceration of the digestive tract
  • Lethargy
  • Delayed wound healing

A study conducted in 2015 revealed that dogs under corticosteroid treatment had shown adverse behavioral changes (29 ) .

It is also important to note that Dogs who are suffering from infections like fungal infections should not be given Prednisone. Corticosteroids will bring these out, even latent infections (30 ) .

Prednisone should also not be taken with drugs prone to causing ulcers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), as doing so can result in stomach ulcers.

Natural Alternatives to Prednisone for Dogs

Because of Prednisone’s side effects on a dog’s body, some pet owners are turning to natural alternatives for their pet’s medical conditions.

Yucca Schidigera and Dogs

For joint pain and inflammation, Yucca Schidigera is a recommended natural alternative. Its extracts have anti-arthritic and anti-inflammatory effects (31 ) .

Yucca is a medicinal plant from Mexico. It is available in tablet form.

Turmeric and Dogs

Instead of treating dogs with anti-inflammatory drugs, turmeric is a good alternative. A 2009 study shows that turmeric, particularly its curcumin compound, can be used to treat inflammation (32 ) .

Aside from being anti-inflammatory, turmeric also has antibacterial, antitumor, and antioxidant properties (33 ) .

CBD Oil and Dogs

Another natural alternative to Prednisone for dogs is CBD (Cannabidiol) oil, a non-psychoactive cannabinoid.

Most CBD benefits are reported on humans, especially its positive effects on epilepsy, anxiety, and different types of chronic pain (34 ) . However, it is suggested that the system that regulates the functions of cannabinoids, the endocannabinoid system (ECS), is the same for all animal species except insects (35 ) .

If the ECS of a human and a dog work the same way, it is suggested that CBD oil can be given to dogs as well.

According to a 2017 article (36 ) , CBD shares metabolic pathways with anti-inflammatory drugs. Thus, it can help alleviate the inflammatory conditions Prednisone treats.

A 2018 study concluded that dogs suffering from osteoarthritis experienced a significant decrease in pain when they were administered with CBD oil. They were also perceived to be more comfortable and active (37 ) , with no adverse effects when they were observed short-term.

Prednisone treats shock in dogs because of its ability to improve circulation. Similarly, studies have shown that CBD reduces high blood pressure and heart rate in stressful situations (38 ) .

The 2017 study also revealed that CBD increases cerebral blood flow (39 ) .

CBD can also help treat a dog’s itchy skin. Its protective role of the ECS could help reduce allergy in the skin (40 ) .

A study also discusses CBD’s role as a potent inhibitor of cancer growth and spread. The research also suggests that CBD can be combined with classical chemotherapeutic agents (41 ) .

Once CBD is used alongside chemotherapeutic agents, their dose and toxicity are reduced while the efficacy is maintained.

While Prednisone alleviates asthma symptoms, CBD could also be as effective.

A study in 2015 states that CBD’s immunosuppressive and anti-inflammatory properties could help in the treatment of asthma (42 ) .

Despite these benefits, CBD also has side effects like dry mouth, lowered blood pressure, and drowsiness (43 ) .

The U.S. Food and Drug Administration has not approved CBD use, so a dosing chart for dogs is not available.

Dog owners should administer small amounts of CBD at first and then monitor its effects. CBD can be given orally, combined with pet food, or used in massages.

Before including CBD in the dog’s regimen, it is recommended that pet parents inform their veterinarian first.

CBD and Prednisone

CBD and Prednisone should not be taken together. The liver enzyme cytochrome P450 metabolizes Prednisone for it to take effect on the body.

A study shows that CBD inhibits the enzyme system, thereby raising risks like amplifying Prednisone’s side effects (44 ) .

Conclusion

Prednisone can be used on dogs. Short-term use already presents side effects, but the more concerning ones come from large doses and long-term use of the drug.

For inflammation in dogs, the dosage of Prednisone is 0.5mg per pound. For immune system disorders, the dosage is 1mg per pound.

Using Prednisone on pets for an extended period of time could bring about adverse effects; hence, natural alternatives like CBD oil are recommended.

CBD oil helps treat the symptoms Prednisone is used for sans the adverse effects. These symptoms include inflammatory conditions, arthritis, shock, skin conditions, cancer, and asthma.

Pet owners should consult with their veterinarian before giving CBD to their dogs.

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