Can You Take CBD Oil With Levothyroxine? Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), Can you take CBD and levothyroxine together? Let’s talk about the CBD-drug interactions with your endocrine system. Learn how the popular CBD compound affects your thyroid health in this article.. Learn more about hypothyroidism with Paloma Health
Can You Take CBD Oil With Levothyroxine?
Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), ingestion of food (drug-nutrient interactions), or ingestion of dietary supplements (dietary supplement-drug interactions).
Drug-drug interactions result when two or more drugs react with each other. Such drugs can be from a combination of prescription drugs and/or over-the-counter (OTC) medications. Drugs with a narrow therapeutic range (little difference between therapeutic and lethal dose) are more likely to face incidents of serious drug interactions.
What is levothyroxine?
Levothyroxine is a prescription medicine used to treat an underactive thyroid gland (hypothyroidism). The thyroid gland makes thyroid hormones that help to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone thyroxine.
Levothyroxine belongs to a class of drugs called hormones. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. About 40-60% of orally administered levothyroxine is absorbed; the majority from the jejunum and upper ileum of the gastrointestinal tract. Absorption is increased when levothyroxine is taken on an empty stomach. Levothyroxine works by providing the thyroid hormone that your thyroid gland would produce if it were working normally.
About 1 to 2 weeks after you start treatment with levothyroxine, you will likely notice that your levels of fatigue have improved. It is important that you take your medication exactly as prescribed and not miss any doses as well as maintain routine checkups with your primary health care provider.
What is CBD oil?
Cannabidiol (CBD) oil is a product that’s derived from cannabis. It’s a type of cannabinoid, which are the chemicals naturally found in marijuana plants. Even though it comes from marijuana plants, CBD doesn’t create a “high” effect or any form of intoxication — that’s caused by another cannabinoid, known as THC. This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of cannabis or other side effects related to some pharmaceutical drugs.
CBD oil is made by extracting CBD from the cannabis plant and then diluting it with a carrier oil like coconut oil or hemp seed oil. CBD can be found in a variety of products online and in stores, including dietary supplements, bath soaks, drinks, and food.
It continues to gain momentum in the health and wellness world, with some scientific studies finding that it may ease symptoms of several conditions. A high-quality CBD oil may address a variety of thyroid dysfunctions. This underperformance includes hypothyroidism, hyperthyroidism, goiter, thyroiditis, and thyroid storm. All of the above conditions are triggered by chronic inflammation of the thyroid gland due to the body’s autoaggressive actions on this organ.
We know that endogenous cannabinoids (the ones produced by our bodies) help regulate our appetite, energy, homeostasis, and influence endocrine glands, including the pituitary gland and thyroid gland. Research does not yet know how external cannabinoids (like CBD oil) affect these glands and your serum thyroid hormones concentrations like TSH and T4.
A 2015 study found significant concentrations of CB1 and CB2 cannabinoid receptors in the thyroid glands. These receptors were associated with the shrinkage of thyroid tumors, showing promise as potential blockers of the spread of malignant cells on the gland.
Can you take CBD oil with levothyroxine?
No, you should never take CBD oil with levothyroxine together, because taking CBD oil with other medications that have similar effects like levothyroxine may increase the risk of unwanted symptoms or toxicity.
In addition, taking CBD oil while on levothyroxine treatment can lead to hyperthyroidism, a condition where your thyroid makes and releases high levels of thyroid hormone. This condition can speed up your metabolism. Symptoms of hyperthyroidism include a rapid heartbeat, weight loss, increased appetite, and anxiety.
Researchers are working to determine the specific interactions between CBD and various medications. Studies have been done on animals for certain medications, but in many cases, scientists are still determining how those results translate to humans.
CBD and Levothyroxine: What Happens When You Mix Them Together?
Levothyroxine is a popular thyroid medicine that serves as a substitute for a hormone that the thyroid gland should naturally produce to regulate the metabolism, growth, and development of the body. When the thyroid is unable to do this on its own, this disorder is called Hypothyroidism
CBD oil is an alternative treatment for hypothyroidism. Like most other diseases, inflammation is also a significant contributor to hypothyroidism, and CBD is famous for its anti-inflammatory properties.
Levothyroxine and Hypothyroidism Treatment
Levothyroxine may be the most commonly known treatment for hypothyroidism, which means an under-active thyroid gland. The primary job of the thyroid gland is to secrete thyroid hormone which helps to regulate the body’s metabolism and growth. Once the gland has become incapable of producing this hormone, levothyroxine acts as a substitute for the missing thyroid hormone.
Levothyroxine comes in either an oral or injectable form, and it is strictly on prescription. The oral form could either be a tablet or capsule. Oral levothyroxine tablets may need to be taken with other medications as they are primarily for part of combination therapy. Levothyroxine also helps in the treatment of goiter and certain types of thyroid cancer.
CBD and Hypothyroidism Treatment
A study evaluated the clinical significance of CB1 and CB2 expression in the human body and found out they are highly concentrated, especially in the thyroid gland. These receptors showed the potential for serving as a blocker to the spread of malignant cells present in the thyroid gland.
Another study has found that CBD may be effective in easing chronic inflammatory and neuropathic pain. These receptors in rat thyroids seemed to be capable of influencing the T3 and T4 hormone release. The study was conducted on rats and, as such, hasn’t been verified in humans.
There is a significant need for more studies on how CBD oil helps with the thyroid in humans. However, the research conducted so far has shown a lot of promise on CBD’s effect on hormonal activities. CBD may also help treat the symptoms associated with thyroid conditions, such as pain, weight gain, fatigue, depression, and anxiety.
Interaction Between Levothyroxine and CBD oil
Knowing that both levothyroxine and CBD oil serve the same purpose, which is treating hypothyroidism, you may wonder if it’s appropriate to use both forms of medication simultaneously. This is where you need to consider potential CBD-drug interactions. CBD oil and levothyroxine compete for metabolism, and they both require the same pathway to metabolize, which is the cytochrome P450.
A study in 2017 discovered that if a patient takes both levothyroxine and CBD oil simultaneously, this may result in a case where more thyroxine becomes compiled before the body metabolizes it due to the aforementioned interaction. When this happens, it results in another disease called Hyperthyroidism. Other risks involved with the interaction of levothyroxine and CBD oil involve anxiety and mild nausea.
However, if a patient spaces out the time frame between the use of Levothyroxine and CBD oil, there may be minimal or no effect at all, as found in a couple of patients. Nonetheless, you will need to consult your doctor to establish the right routine for both compounds.
Choosing Between Levothyroxine and CBD oil
Now you know that using both levothyroxine and CBD oil is not entirely risk-free, except when it is well-spaced — and even at that, you may need a doctor’s supervision.
So, before you go on with deciding on whether or not you should include CBD in your supplementation plan, let’s take a look at the pros and cons of both substances.
Like every other medication, both levothyroxine and CBD oils have their advantages and disadvantages. We will be looking at some of these, starting with levothyroxine.
Pros of Using Levothyroxine
- Safe for all ages and pregnant women: Levothyroxine is certified safe for adults and children, even as young as one to five years. It is also safe for pregnant women, unlike some drugs that are not advisable for women to use during pregnancy.
- Easy to use: Using levothyroxine is relatively easy compared to some other drugs, as you only have to take it once a day. Also, it’s not necessary to use it in the morning alone; if you have busy morning schedules, you can choose to use your levothyroxine at night.
- Affordability: For a substance that is quite beneficial in treating a crucial disorder, levothyroxine is somewhat cheap and affordable.
Cons of Using Levothyroxine
- Interaction with food and other medications: It is best to use levothyroxine on an empty stomach as other drugs or even food may interact with it and, as a result, hinder it from being effective. Patients should use levothyroxine an hour before eating or using other medications.
- It takes a long time to figure out the correct dose and see the result: The right dose for levothyroxine varies from one person to another. As a result, it might take weeks or even months to find the correct dose because you can’t figure out if the medication is working for 6-8 weeks, which is the time frame to see the full effect of levothyroxine. Sometimes, you may require a routine blood test to ensure you are using the correct dose.
- You have no liberty of missing doses: If you forget to use your medication a few times, you will start feeling all the symptoms associated with hypothyroidism again. These symptoms include fatigue, constipation, dry skin, and weight gain.
Pros of Using CBD oil
- CBD is a versatile therapeutic compound: It modulates the endocannabinoid system (ECS), resulting in the regulation of hormonal activity. Therefore, it has the potential to help with thyroid disorders and associated symptoms.
- Easy to get: CBD oil is legal in most places in the world. You can buy CBD without a prescription from a doctor.
- It is non-addictive: A study proved that CBD is not habit-forming, unlike the whole cannabis itself. This makes CBD safe for daily consumption.
Cons of using CBD oil
- Not enough practical evidence: There are limited studies on the effect of CBD oil when it comes to treating thyroid disorders in humans.
- Interaction with other drugs: CBD tends to often interact with other medications, thereby bringing a counter-productive result. This theory was deduced in a 2017 research. Hence, it is essential to consult with a doctor who has vast experience in cannabis use before you embark on starting a CBD product.
- Most CBD products are unregulated: Most CBD products sold randomly online are not regulated, and as such, it may be difficult to find out if the product contains what the label claims.
How to Choose the Right CBD for Hyperthyroidism and Other Thyroid Diseases?
Cannabinoids aren’t the only beneficial compounds in cannabis. Other phytonutrients include terpenes, flavonoids, amino acids, essential oils, and tetrahydrocannabinol (THC). If you want to enjoy the benefits of all these nutrients, then you should opt for full-spectrum CBD.
However, if you don’t want to ingest even trace amounts of THC, you can go with the broad-spectrum CBD. This option has a similar phytochemical profile to the full-spectrum CBD — except for THC.
Isolates are the purest form of CBD because they don’t contain other compounds from hemp. They’re flavorless and odorless and contain the highest amount of CBD per serving. However, unlike the two above formats, CBD isolate doesn’t leverage the whole-plant synergy, making it the least desired type of cannabidiol.
Once you’ve decided on the type of CBD you want to go for, there are still a few details to keep in mind. These include:
- Buying only from reputable manufacturers. CBD brands are sprouting every month, and it may be hard to figure out which ones produce high-quality products; hence, it is necessary to do your research before making a purchase.
- Request a Certificate of Analysis (CoA) of the product you want to buy. Companies that fail to provide these documents aren’t worth your trust because they might have something to hide about the quality of their products.
- Consult a doctor experienced in using CBD or cannabis with their patients. Doing so will help you avoid negative interactions with thyroid medications and figure out the right dosage for your situation.
- When purchasing from an online store, be sure to check user reviews, as this will give you insight into how good the product is. Also, if you are making a physical purchase, find out if the store is legally authorized to sell CBD products.
How to Use Levothyroxine?
Here are some useful tips for taking Levothyroxine if you have a thyroid disorder:
- For maximum effect, you should take levothyroxine on an empty stomach. Doing this will make the absorption process go on smoothly without interference of any form.
- Please pay attention to your diet while on levothyroxine because some particular food may work against it in the body. These foods include soybean flour, walnuts, and cottonseed meal.
- Conduct blood tests to figure out if you are on the correct dose because anything short of that will cause levothyroxine to be ineffective in your body.
How to Use CBD Oil?
CBD can be taken in many different forms. If you’re new to CBD, you may want to consider oral forms, such as gummies or capsules. They offer a fixed dose of CBD per serving and provide longer-lasting effects despite a delayed onset.
For a faster effect, you can go for tinctures and drops. This format works by placing a dose of CBD under the tongue with a dropper; after 60 seconds, you swallow the oil. You will start seeing the effect in 15–30 minutes, and the results should last for about 4–6 hours.
Vaping offers the fastest and most effective way to deliver CBD to your system because it uses the lung tissue for absorption. The effects are almost instantaneous — kicking in after 5 minutes — but they last shorter than other forms. On the other hand, vapes come with the highest bioavailability of CBD.
The time it takes for CBD oil to work on your system depends on how you consume CBD. Some need anywhere from a few minutes while others a couple of hours.
Over the years, Levothyroxine has been a reliable treatment option for hypothyroidism and will continue to be. However, CBD oil is showing the potential of being worthy competition for levothyroxine, and if there is more research on how effective CBD oil can be in treating hypothyroidism and other thyroid disorders such as chronic lymphocytic thyroiditis, it will become even more popular among patients with hypothyroidism.
While both substances may effectively treat hypothyroidism, you shouldn’t take them simultaneously. If you do this, it may lead to another dysfunction like hyperthyroidism. However, if you space out the usage, the risk of both drugs interacting and becoming counterproductive can be reduced to a bare minimum.
Regardless of your choice, make sure to consult a doctor before starting your CBD treatment. A qualified health professional will be in the best position to help you figure out the right dosage and establish a safe routine to avoid interactions with medications.
- Eleftheria, L., Constantinos, G., Maria, T., Paraskevi, A., Ioanna, D., Ioanna, G., George, K., Efstratios, P., & Stamatios, T. Clinical significance of cannabinoid receptors CB1 and CB2 expression in human malignant and benign thyroid lesions. 2015. (1)
- Wei, X., Tanxing, C., Kejung, C., Fei, Y., Shao-Rui, C., Dan, W., Yun, G., Hui-Lin, P., Ke, R., Yan, X., & Li, Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting g3 glycine receptors. 2012.
- Researching marijuana for therapeutic purposes: The potential promise of Cannabidiol (CBD). 2015.
- Kimberly, L., & Susan, L. CBD for Thyroid health. 2021.
- Echo. Can CBD help with thyroid disorders? 2017.
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
How Does CBD Affect Your Thyroid Hormones?
CBD has taken the health community by storm. Indeed, this chemical compound appears in nearly all types of products, addressing all kinds of health concerns. From supplements and oils to shampoos and cosmetics, CBD is seemingly in all sorts of health goods. Because CBD has been widely available for so little time, we are still trying to learn precisely how it affects different body systems. For people with a thyroid condition, this is what we know so far about how CBD affects your thyroid gland and related thyroid hormone levels.
What is CBD?
CBD stands for cannabidiol. It is one of the most active ingredients of cannabis (or marijuana). It is in higher quantities in its sister plant, hemp. CBD does not create a “high” or have a psychoactive component like THC when used alone.
CBD is an oil extracted from hemp seeds. This oil is often full of healthy fats, often appearing in beauty products such as moisturizers and facial serums.
One of the most well-known and proven medical uses for CBD is managing certain types of epilepsy, especially in children. Indeed, even an FDA-approved medication (Epidiolex) contains CBD to treat a particular type of seizure condition. Beyond treating certain types of epilepsy, there is no concrete scientific evidence supporting using CBD to treat other health conditions.
With that said, numerous people and their health providers believe that CBD helps with a robust amount of health complaints and conditions, such as chronic pain, cancer pain, and joint pain.
Despite the absence of enough scientific evidence, people also use CBD oil is to anecdotally help with:
- Sleep issues
- Anxiety disorders (PTSD, panic disorders, etc.)
- Topical pain relief
- Reducing inflammation
- Hot flashes
- Neurodegenerative diseases
The endocrine and endocannabinoid systems
The endocrine system
The endocrine system is the collection of glands that release hormones. Hormones are chemical messengers that help one part of the body communicate with another part of the body.
Endocrine glands are throughout the body, and hormones constantly give and receive feedback to keep the body functioning optimally. The hypothalamus, pituitary gland, and pineal gland are all located in the brain. The thyroid and parathyroid glands are in the neck. The thymus is between your lungs. The adrenal glands are on top of your kidneys. The pancreas is behind your stomach. Ovaries or testes are located in the pelvic region.
Levels of hormones naturally fluctuate depending on the time of day and stage of life (for instance, pregnancy or menopause). However, hormones can also become imbalanced in a way that requires treatment from your healthcare provider. Such is the case with hypothyroidism, the condition in which an underactive thyroid gland does not produce enough thyroid hormones.
As part of the endocrine system, the thyroid gland helps regulate the body’s metabolism in the form of blood pressure, blood temperature, and heart rate. When your thyroid hormone production drops, your body processes slow down and change.
The endocannabinoid system
Science is starting to understand how the body responds to cannabinoids. Endocannabinoids are molecules that the body produces naturally in small amounts that act on cannabinoid receptors. The endocannabinoid system is a highly complex cellular signaling system that plays an important modulatory role in the brain, endocrine, and immune functions.
The endocannabinoid system in the body plays a role in:
In particular, the endocannabinoid systems seem to play a critical role in regulating reproductive hormones and our stress response. This system also helps to control food intake and related energy expenditure.
Within this system, the mechanics include endocannabinoids, cannabinoid receptors, and enzymes. The body naturally produces endocannabinoids, which are molecules that are similar to cannabinoids. The cannabinoid receptors within this system respond to endocannabinoids, but they also bind to THC, which is one reason why THC can have so many effects on your body,
Because CBD is different from THC, it has a different interaction with the endocannabinoid system. CBD does not appear to bind to receptors like THC but instead may prevent endocannabinoids from breaking down or attaching to a receptor for which researchers have not yet been able to identify.
Does CBD impact thyroid hormones?
Because the endocannabinoid system has the potential to affect every system in the body, there is potential that CBD may influence your endocrine system, too.
We know that endogenous cannabinoids (the ones produced by our bodies) help regulate our appetite, energy, homeostasis, and influence endocrine glands, including the pituitary gland and thyroid gland. Research does not yet know how external cannabinoids (like CBD) affect these glands and your serum thyroid hormones concentrations like TSH and T4.
What does using CBD mean for people taking thyroid medication?
Cannabinoids and thyroid hormones both play a role in regulating your metabolism. While we do not know exactly how CBD affects your metabolism, there is potential that synthetic thyroid hormone replacement medication and CBD may compete to regulate your metabolism.
Aside from uncertainties in how CBD and thyroid medication interact, there is some evidence that CBD helps reduce inflammation, which is at the root of Hashimoto’s disease, one of the leading causes of hypothyroidism. Indeed, it has immunosuppressant-like qualities, making it a potentially valuable substance for certain autoimmune diseases like Hashimoto’s.
Suppose you have a thyroid condition and are managing it with medication. In that case, you need to practice caution when introducing other substances which may alter your system.
Your Guide To Thyroid Medication
Optimizing your thyroid levels with thyroid hormone replacement medication is usually the first step in minimizing symptoms.
What should I do if I want to try a CBD product?
Finding balance in your thyroid levels can take a significant amount of trial and error and time. People often need to try different doses of thyroid hormone medication to see what brings their thyroid hormones to a therapeutic level. Many people also find that factors outside their medication can also throw off their thyroid function, including taking new medications and making diet changes.
If you want to try CBD, you should first check with your doctor to see if it is safe for you. It is important to know that CBD is not a regulated substance if you do get the go-ahead. The FDA considers it a dietary supplement, which are not generally monitored for quality, safety, and efficacy. This means that there is likely a lack of standardization in some CBD formulations. Thus, concentrations and strengths may differ, even in the same brand.
It is also important to keep in mind that some CBD manufacturers may make false claims of how CBD is a cure-all, even for diseases like cancer. Because there is little regulation on CBD and no concrete evidence for treating health conditions other than some types of epilepsy, it is best to explore using CBD in partnership with your doctor.
If you choose to try CBD and have checked with your doctor to rule out medication interactions, try to separate when you take your thyroid medication from when you use CBD to minimize the impact on the absorption of thyroid medication.