Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and oxidative stress. Current AD treatments do not stop or reverse the disease progression, highlighting the need for new, more effective therapeutics. Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has demonstrated neuroprotective, anti-inflammatory and antioxidant properties in vitro. Thus, it is investigated as a potential multifunctional treatment option for AD. Here, we summarize the current status quo of in vivo effects of CBD in established pharmacological and transgenic animal models for AD. The studies demonstrate the ability of CBD to reduce reactive gliosis and the neuroinflammatory response as well as to promote neurogenesis. Importantly, CBD also reverses and prevents the development of cognitive deficits in AD rodent models. Interestingly, combination therapies of CBD and Δ 9 -tetrahydrocannabinol (THC), the main active ingredient of cannabis sativa, show that CBD can antagonize the psychoactive effects associated with THC and possibly mediate greater therapeutic benefits than either phytocannabinoid alone. The studies provide “proof of principle” that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies. Further investigations should address the long-term potential of CBD and evaluate mechanisms involved in the therapeutic effects described.
Keywords: Alzheimer’s disease; cannabidiol; therapy; transgenic mouse model; Δ9-tetrahydrocannabinol.
CBD is closely related to another medically active phytocannabinoid: tetrahydrocannabinol (THC). This component is the reason why cannabis is commonly known as a recreational drug.
The medicinal potential of CBD has been found to help a wide range of diseases, as this compound has achieved results that were not possible with traditional medicine, such as relieving side effects of conventional treatments. The therapeutic aspects of CBD have shown to help the following diseases:
3 things you may not know about CBD
3 things you did not know about CBD
Cannabidiol and Tetrahydrocannabinol
CBD is extracted from the cannabis flower, and its medicinal properties have been scientifically and medically proven by experts all over the world. It is a safe substance that is neither addictive nor does it produce hallucinogenic effects. For centuries, CBD was used for its healing properties, but as cannabis became popular as a recreational drug, things got a bit more complicated .