In a recent study published by the Journal of Psychopharmacology, the authors found that CBD reduced anxiety and tremor amplitude among PD patients. The research team used a dose of 300 mg CBD/day, which provided significant benefits for heart rate, blood pressure, and frequency of tremors among the subjects .
The authors concluded that more research would help establish CBD’s clinical value on brain injury and stroke.
CBD Oil for Anxiety Tremors
So, while temporary tremors aren’t an alarming sign, chronic episodes may indicate a serious disease requiring medical attention.
CBD can also interact with many pharmaceutical substances , so consult your doctor before adding CBD to your daily routine if you take any medications.
CBD Oil vs. Brain Damage Tremors
When CBD regulates these receptors, it produces relaxing and antispasmodic effects; it can also block the release of pro-inflammatory proteins known to damage the nervous system.
This is exactly why the IETF is so pleased to support Dr. Handforth and this cutting-edge research with a nearly $20,000 grant. “The significance of this work is two-fold,” says Dr. Handforth. “First, finding that CBD suppresses tremor in an animal model may provide justification for a clinical trial of CBD for essential tremor in humans. Second and more importantly, if we can understand how CBD stops the tremor, what mechanisms are at work, then an ET-specific medication could be developed that would be better-tolerated and more effective than what it available today.”
Testing a variety of doses, Dr. Handforth was able to note a robust suppression of tremor in the mice given CBD, without the animals showing any signs of impairment or sedation. Next, the team worked to discover what receptors in the brain might be involved in the noted effects. After looking at several options the information suggests that CBD activates the 5HT1a receptors to suppress tremor by activating the TRPV1 receptor.
Cannabidiol Anti-Tremor Action & Mechanisms – Conclusion
Cannabis, also known as marijuana, has been used for medicinal purposes for thousands of years. However, by federal law, the possession of cannabis is illegal in the United States, except within approved research settings; however, a growing number of states, territories, and the District of Columbia have enacted laws to legalize its medical use.
“People tend to think of medical marijuana as a single substance; a substance that may have beneficial effects but also causes mood- and mind-altering effects,” explains Dr. Adrian Handforth, Assistant Chief of Neurology at VA Greater Los Angeles Healthcare System in California, “But that is not the case at all. Actually, marijuana is made up of many related chemicals, called cannabinoids.”
Dr. Adrian Handforth is the Chief of Neurology at VA Greater LA Healthcare System. He is the lead researcher of an IETF-funded study that explores the effects of CBD on essential tremor. Dr. Handforth and his team seek to determine whether CBD can suppress ET in an animal model.
Essential tremor is a nervous system (neurological) disorder. It is characterized by involuntary and rhythmic shaking, which can occur in any part of the body. It most commonly occurs in the hands when performing simple tasks like drinking from a glass or tying shoelaces.
Emotional stress, fatigue, caffeine, or temperature extremes may aggravate this condition. However, people should not confuse essential tremor with what doctors consider to be physiologic tremor.
One final treatment method revolves around the use of MRI to focus ultrasound. The idea is to destroy the tissue located in the thalamus. One significant downside is that patients stay awake during the procedure, which isn’t a pleasant experience.
Despite how common ET is, there is no cure, and there are currently very few treatment options available.
What Is an Essential Tremor?
In theory, cannabidiol targets and regulates the endocannabinoid system (ECS) receptors, CB1 and CB2. These are found in the brain and throughout the body and help regulate bodily functions such as muscle movement.
According to researchers, this new approach avoids affecting the neurons in the brain responsible for our cognitive abilities and memory. Therefore, it is possible to provide patients with involuntary shaking an effective treatment that doesn’t lead to certain marijuana side effects. The next step is to perform clinical trials on patients with ET to see if this approach has the same impact on humans.