CB1Rs are mainly in the brain, particularly in the substantia nigra, the basal ganglia, limbic system, hippocampus and cerebellum, but are also expressed in the peripheral nervous system, liver, thyroid, uterus, bones and testicular tissue [Russo and Guy, 2006; Pagotto et al. 2006; Pertwee, 2006]. CB2Rs are mostly expressed in immune cells, spleen and the gastrointestinal system, and to some extent in the brain and peripheral nervous system [Izzo, 2004; Pertwee, 2006]. Interestingly, both CB1 and CB2Rs are also found in human placenta and have been shown to play a role in regulating serotonin transporter activity [Kenney et al. 1999]. Indeed further research has revealed that the endocannabinoid system also plays a significant role in various aspects of human reproduction [Taylor et al. 2010].
Brief history of the biochemistry of the cannabis plant
However, only a small minority develop a full-blown psychotic illness in the form of schizophrenia or bipolar disorder, whilst a larger group, ranging from 15% to 50%, experience transient psychotic symptoms of brief duration, from a couple of hours to up to a week, and usually recover without requiring any intervention [Thomas, 1996; Green et al. 2003; D’Souza et al. 2004, 2009; Morrison et al. 2009]. Indeed drug challenge studies with d-9-THC on healthy volunteers have shown a broad range of transient symptoms, behaviours and cognitive deficits ranging from anxiety to psychosis to transient memory disturbance [D’Souza et al. 2004; Curran et al. 2002; Morrison et al. 2009]. The clinical picture of transient psychosis can be indistinguishable from a frank acute psychosis with delusions and hallucinations, except for its short duration.
Different strengths of street cannabis
In the brain, CB1Rs are found at the terminals of central and peripheral neurons, where they mostly mediate inhibitory action on ongoing release of a number of excitatory and inhibitory dopaminergic, gamma-aminobutyric acid (GABA), glutamatergic, serotoninergic, noradrenalin and acetylcholine neurotransmitter systems ( Figure 1 ). Because of the involvement of these systems they affect functions such as cognition, memory, motor movements and pain perception [Howlett et al. 2002]. The release of endocannabinoids, such as AEA and 2-AG, from the postsynaptic sites to the synaptic cleft occur in response to elevation of intracellular calcium and they then act as retrograde neurotransmitters on presynaptically located CB1Rs to maintain homeostasis and prevent the excessive neuronal activity [Howlett et al. 2002; Terry et al. 2009]. They are then rapidly removed from the extracellular space by cannabinoid transporters, often referred to as anandamide membrane transporters, which facilitate their breakdown by internalizing the molecule and allowing access to fatty acid amide hydrolase [Pertwee, 2010]. Despite its significance in the endocannabinoid system, little is known about the cannabinoid transporters.
For more information, read our blog post on what CBD oil is .
Good Hemp’s hemp oil is super-rich in omegas (otherwise known as good fat) and has 25 times more omegas than olive oil. It has absolutely no trans fats (and 40% less saturated fats than olive oil).
CBD can be extracted from both marijuana and hemp. However, as marijuana is illegal in most places, much of the CBD you’ll find on the market is made from hemp.
What are the benefits of CBD oil?
It’s perfectly safe to take hemp oil and CBD oil at together. Even combining different CBD products is considered a completely safe thing to do.
No, CBD will not get you high because CBD is another one of the many compounds found in cannabis plants (so in both hemp and marijuana) which has no psychoactive properties.
What are the benefits of Good Hemp Oil?
Yes, hemp oil can be good for pain. Hemp seed oil is applied topically or ingested by many people as a form of natural pain relief. It has anti-inflammatory properties that can be useful for people suffering from a variety of painful infections, autoimmune disorders or injuries.
Put simply, CBD restores homeostasis (the body’s natural balance). It works in the endocannabinoid system by activating two of its core receptors (known as CB1 and CB2), which regulate mood, temperature, cognitive function and muscle repair.