cbd trials for schizophrenia

Cbd trials for schizophrenia

Reduction of enforcement measures, improved acute treatment, harm reduction, and improvement of psychotic symptoms

Interventional study using Cannabidiol containing cigarettes as replacement of usual cigarettes

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Resource links provided by the National Library of Medicine

Englund A, Morrison PD, Nottage J et al (2013) Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol 27:19–27. https://doi.org/10.1177/0269881112460109

Bhattacharyya S, Morrison PD, Fusar-Poli P et al (2010) Opposite effects of δ-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology 35:764–774. https://doi.org/10.1038/npp.2009.184

The potentially confounding effects of recreational cannabis and over-the-counter cannabinoids

Gibbs B, Yates DA, Liebling J (2019) CBD in the UK. Centre for Medicinal Cannabis, London

McGorry PD, Nelson B, Amminger GP et al (2009) Intervention in individuals at ultra-high risk for psychosis: a review and future directions. J Clin Psychiatry 70:1206–1212. https://doi.org/10.4088/JCP.08r04472

The mechanism of action of CBD in psychosis

A single in vitro study reported that CBD may act as a partial agonist at dopamine D2 receptors (Seeman 2016). This was the first study to report such an effect and it requires replication. Moreover, if CBD is primarily acting on dopaminergic pathways, it is surprising that it does not cause akathisia, an effect which is observed with all other partial agonists (Frankel and Schwartz 2017).

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