cbd weed without thc

Cbd weed without thc

The first thing to know about CBD is that it is not psychoactive; it doesn’t get people high. The primary psychoactive ingredient in marijuana is tetrahydrocannabinol (THC). But THC is only one of the scores of chemicals – known as cannabinoids – produced by the cannabis plant.

The perception of its widespread medical benefits have made the chemical a rallying cry for legalization advocates.

At age five, Charlotte suffered 300 grand mal seizures a week, and was constantly on the brink of a medical emergency. Through online research, Charlotte’s desperate parents heard of treating Dravet with CBD. It was controversial to pursue medical marijuana for such a young patient, but when they gave Charlotte oil extracted from high-CBD cannabis, her seizures stopped almost completely. In honor of her progress, high-CBD cannabis is sometimes known as Charlotte’s Web.

Cbd weed without thc

1 Cancer Signalling Research Group, Medical Biochemistry, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; [email protected] (F.A.); [email protected] (M.C.); [email protected]ayR (R.J.D.); [email protected] (A.M.D.); [email protected] (C.G.)

Alicia M. Douglas

Cannabinoid induced anti-cancer crosstalk between G-protein-coupled receptor (GPCR) and non-GPCR signalling pathways is significant and complex. Cannabinoids interact with CB1R and CB2R and with non-cannabinoid receptors (CBRs) GPCRs (discussed in Section 3.3) to induce cancer cell death via promotion of cellular stress response pathways, increased ceramide synthesis, and reduced oncogenic growth and proliferation signalling.

3.2.2. De-Orphaned G-Protein-Coupled Receptor 55

Transient receptor potential channels of the vanilloid subtype proteins and G-protein-coupled receptors mediates the anti-cancer effects of non-tetrahydrocannabinol (non-THC) cannabinoids. Cannabidiol (CBD) antagonises the de-orphaned G-protein-coupled receptor GPR55, and agonise transient receptor potential vanilloids (TRPVs), TRPV1 and TRPV2. CBD may out-compete the natural ligands of orphaned G-protein-coupled receptors (GPCRs), GPR3, GPR6 and GPR12, and this in turn suggests a mechanism for the inhibition of tumour growth and the induction of cell cycle arrest, and/or may even promote selection of cancer stem cells (CSCs).