Next, add the crude and gently warm everything until it’s all mixed together.
Tools & Materials Needed
THC remediation is the process of removing THC from a cannabis extract in order to increase the purity of CBD or other individual cannabinoids or to comply with legal requirements when manufacturing CBD or delta 8 THC products.
Frequently Asked Questions
Lewis acids tend to be better at converting CBD to delta 8 THC, while Brønsted acids tend to be better for converting CBD to delta 9 or delta 10 THC (there are exceptions to this rule).
There are reported methods and patents for converting CBD into THC and for maximizing THC production, but what about the other way around? Could there be a way to convert psychoactive THC into non-psychoactive CBD?
Mechanisms for opening THC.
The field of natural product synthesis specializes in these types of transformations, to be able to convert one structure to another in order to access a natural product target either from simple commodity chemicals (total synthesis) or another natural product (semisynthesis). The conversion of THC to CBD would be classified as semisynthesis, since the starting material is another natural product – THC. Semisyntheses can have an advantage that the starting material is often similar in structure to the product, thus requiring fewer steps. However, some molecular targets cannot easily be accessed by semisynthesis, but their unique structure can be made from scratch, essentially, using organic chemistry methods to construct the scaffolds from chemical feedstocks. Both total synthesis and semisynthesis are used industrially for different purposes, and both strategies incorporate the same organic chemistry principles when designing a route.
Usually, reactions done on a small scale (15 mg of starting material was used) are not directly applicable to an industrial scale without substantial effort. Since it was a final step, they did not need to optimize the reaction to be environmentally friendly or cost effective, as it was not a priority for the broad goals of this project. The conditions that they report (dichloromethane as solvent, -78 degree C temperature, BCl3 as a Lewis acid, 2,6-di-tert-butyl-4-methylpyridine as a bulky, more selective base), might not be directly scalable, especially for those with limited experience in synthetic chemistry.