Walking, balance and co-ordination may get worse. Many people have problems with their speech, which will become slow and slurred.
Other problems people with advanced CBD can experience include:
The condition tends to develop gradually, which means it can be mistaken for another condition at first – such as Parkinson’s disease, dementia or a stroke.
As CBD progresses, it may eventually start to cause problems in your other limbs.
Some of the main symptoms of CBD are outlined below. Most people with the condition won’t experience all of these.
Some people with CBD also have dementia, although this doesn’t always occur, symptoms may include:
Some people also develop problems with walking and co-ordination.
If you have CBD, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS).
The diagnosis must be made or confirmed by a consultant with expertise in CBD. This will usually be a neurologist (a specialist in conditions affecting the brain and nerves).
Symptoms can include:
Most cases of CBD develop in adults aged between 50 and 70.
The surface of the brain (cortex) is affected, as well as a deep part of the brain called the basal ganglia.
There is currently no treatment that has been shown to stop CBD getting gradually worse, although treatments can reduce many of the symptoms.
Good care and assistance can help someone with CBD be more independent and enjoy a better quality of life, but the condition will eventually put them at risk of serious complications.
There’s no single test for CBD. Instead, the diagnosis is based on the pattern of your symptoms. Your doctor will try to rule out other conditions that can cause similar symptoms, such as Parkinson’s disease or a stroke.
Difficulty swallowing can cause choking, or inhaling food or liquid into the airways. This can lead to pneumonia, which can be life-threatening.
There is currently no cure or treatment to stop CBD’s progression but medication and various therapies can relieve symptoms and improve quality of life.
Corticobasal Degeneration (CBD) is a rare type of parkinsonism that affects people from the age of 40, typically between the ages of 50 to 70. It tends to affect one side of the body more than the other initially, gradually spreading over a few years.
A diagnosis should be made by a specialist with experience in CBD, usually a neurologist. He or she may ask for a brain scan to rule out other causes, and they may also carry out tests to check memory, concentration, and understanding of verbal communication.
CBD is a very individual condition and the symptoms each person experiences vary. As CBD is a progressive neurodegenerative condition, symptoms gradually become worse over time.
It is thought there may be some weak genetic link too but the risk of other family members developing CBD is very low.
Cognitive and behavioural changes: thinking may become impaired, leading to memory problems and difficulty understanding and interpreting communication. It may also be difficult to carry out complex tasks that require planning ahead.
CBD has similarities with Progressive Supranuclear Palsy (PSP). Some people with CBD go on to develop PSP, and vice versa.
CBD occurs when cells in specific parts of the brain – the cortex and basal ganglia – are damaged as a protein called tau builds up and over time causes harmful clumps. In normal brains, tau is broken down to avoid a build-up, but in CBD this does not happen.