Bipolar patients and pioneering doctors report life changing benefits from CBD, including mood stabilization, the holy grail in bipolar disorder symptom management. Proper brain functioning depends on the communication between neurotransmitters. CBD can promote balance in the nervous system, showing potential in the treatment of a bipolar disorder. Learn how to use CBD as a mood stabilizer. CBD has been touted to help a number of mental health conditions. Learn if there is any evidence of CBD helping people with bipolar disorder.
CBD & Bipolar Disorder
It’s long been accepted that mental health conditions are greatly underserved by current medications and treatments. And none more so than bipolar disorder ( BD ), a debilitating condition in which patients’ moods swing uncontrollably between manic episodes and deep depression. For many, simply existing becomes intolerable, with between 25-60% attempting suicide at some point in their lives. 1
Most BD patients are prescribed a cocktail of drugs that include mood stabilizers like lithium, antidepressants, antipsychotics, anti-anxiety medication, anticonvulsants, and sleeping tablets, often leaving them so medicated they’re unable to function. Eighty-nine percent of BD sufferers report experiencing serious impairment due to their condition (and undoubtedly their medication), more so than any other mental health disorder. 2
As such, self-medication with cannabis and/or alcohol is common, although universally discouraged by health professionals. 3 Indeed, of the clinicians who regularly prescribe cannabis for other health conditions such as anxiety and depression, most give the cannabis plant a wide berth when it comes to bipolar disorder, citing the risk of worsening manic episodes and its link with increasing the risk of psychosis. 4
And yet, anecdotal evidence both from patients and the few pioneering doctors are reporting some life changing benefits from CBD -rich cannabis, including mood stabilization, the holy grail in bipolar disorder symptom management.
What Is Bipolar Disorder?
Bipolar disorder, formerly called manic depression, often manifests in adolescence, although it can come on at any time, and affects almost 3% of the US population.
On average, it can take 8 years to get an official diagnosis 5 after a first episode, with younger patients sometimes misdiagnosed with ADHD . 6 However, when the diagnosis eventually comes it’s usually classified as either bipolar I disorder, where one manic episode is preceded or followed by hypomanic or major depressive episodes, including in some cases, psychosis; or bipolar II disorder when patients have had one major depressive episode and at least one hypomanic episode, but never a full-on manic episode.
Because of bipolar disorder’s complex nature, patients are prescribed multiple pharmaceuticals, some of which can actually make certain symptoms worse and leave them feeling like zombies.
Bipolar Disorder, Dopamine, & the Endocannabinoid System
Why BD develops is not completely understood. However, one commonly held theory suggests an imbalance in the dopaminergic system may play a role, 7 with excessive dopamine transmission contributing to the manic phase and increased dopamine transporter levels leading to reduced dopaminergic function and depression. Dopamine is a class of neurotransmitter that plays a role in pleasure, motivation, and learning.
CB2 receptors that modulate immune function may be a therapeutic target for managing bipolar disorder symptoms.
It’s commonly accepted among scientists that the endocannabinoid system acts as a master regulator, maintaining homeostasis in neurological activity and throughout the body. This includes acting as an ‘important filter’ to incoming inputs acting locally in the midbrain and shaping how information is passed onto dopamine neurons. 8
While it’s not clear whether some kind dysregulation within the endocannabinoid system has a causal relationship with BD , authors of the paper, “Endocannabinoid Modulation of Dopamine Neurotransmission” suggest “endocannabinoid-based therapies as valuable treatments for disorders associated with aberrant DA function.” As an aside, CBD is a partial agonist [activator] of the dopamine D2 receptors, which researchers suggest may partly account for its antipsychotic effect. 9
A further line of study, outlined in the 2019 paper ‘Bipolar Disorder and the Endocannabinoid System’, 10 is based on the premise that inflammation plays a role in many mood disorders including BD , and suggests CB2 cannabinoid receptors, considered to have an immunomodulating effect, 11 may be a therapeutic target for managing BD symptoms.
Studies show elevated levels of certain inflammatory pro-cytokines are present in the manic phase and depressive phases of BD and normalise when patients have returned back to a neutral phase. 12
Thus, the researchers posit that reducing inflammation by targeting the CB2 receptors and using selective CB1 receptor antagonists, “may lead to remarkable advances pertaining to pharmacotherapy of BD based on modulation of the ECS , and this approach offers a brand-new treatment strategy to broaden the arsenal available to pharmacologically mange BD .”
A Patient’s Story
Diane Green, 62, from Rocklin, California, first started showing symptoms of bipolar disorder when she was 15. However, it would take over twenty years until she eventually got an accurate diagnosis.
Most of what Diane has held dear in life has been destroyed by BD ; her education, her relationship with her family, her marriages, and her career as a nurse.
“The one thing that I know is being bipolar and being on meds,” she shares. “It touches every part of life… it takes everything away.”
Being bipolar and being on meds touches every part of life. It takes everything away.
Before she got her diagnosis at 38, Diane self-medicated with alcohol and occasionally cannabis to calm her agitation. However, her violent outbursts, agitation, and depression continued unabated, leaving Diane desperate for help.
“Once I called the cops,” she recalls. “They came over and I’m begging him, ‘Please take me to the mental institution.’ He asked me if I was drinking, and I said yes. And he said, ‘Well, they won’t take you, and I remember I went and got in his car anyway.”
While finally getting a bipolar disorder diagnosis was a relief in many ways, it heralded a new phase of her life: coping with the side effects of the various pharmaceuticals she was prescribed.
“The medication is its own nightmare of a journey,” says Diane, “the side effects were shockingly terrible. The fog I was in, it was horrible.”
In fact, according to Diane, rather than improving her depressive episodes, the medication actually made them worse.
“Once they put me on meds is when the depression got to where I could hardly get out of bed at all,” she remembers. “It never stopped the episodes… But it helped take the edge off. So, I still had to go through the cycles, manic depression and rapid cycling.”
CBD to the Rescue
It was in one of her desperate lows that Diane decided to try CBD oil.
“About 45 minutes later, I just noticed I’m calmer,” says Diane. “I’m more relaxed. Something felt better I think because I wasn’t depressed.”
Delighted with the results, Diane started taking CBD everyday, eventually over time carefully coming off her meds (a process best undertaken with the guidance of a health professional). Free from their debilitating side effects, Diane could finally begin to enjoy her life again.
“I just remember the amazement of the mornings with a clear mind and going for walks and just feeling the air and looking at nature,” she recalls fondly. “And that just became so precious to me having a clear mind… I feel like it just balances it out, so that I really don’t have symptoms. Sometimes I forget I’m bipolar.”
It’s taken a bit of experimentation with different CBD products for Diane to find her therapeutic sweet spot. But interestingly, for her at least, rather than whole plant CBD -rich cannabis, it’s actually been 33 mg of CBD isolate taken twice a day that has worked best at managing her symptoms.
After a life dominated by her bipolar disorder, Diane wishes she’d found CBD earlier.
“I think about those hopes and dreams because I wanted a career, I was excited about life in college and getting married someday and having the perfect kids in the perfect house… And all that just gets taken away slowly. It just does… I don’t think with CBD I would have ever had to have gone on disability.”
A Clinician’s Experience
Holistic physician Deborah Malka MD has seen a number of patients with bipolar disorder over the years. Indeed, she is one of only a few clinicians worldwide willing to recommend medicinal cannabis to help manage bipolar disorder symptoms.
In her book ‘Medicinal Cannabis: Pearls for Clinical Practice,’ Malka shares a number of case studies of bipolar patients who have responded favorably to CBD -rich cannabis, and in a conversation with Project CBD she reveals why treating bipolar disorder with cannabis isn’t just about alternating between CBD and THC to manage the manic and depressive cycling.
“I had about 10 patients with bipolar disorder,” says Malka, “and what I found is that most of them responded best to being on some kind of CBD as an ongoing mood stabiliser, to actually prevent the ups and downs.
According to Dr. Malka, because CBD has proven anticonvulsant effects, and anticonvulsants are commonly prescribed for bipolar disorder to complement drugs like Lithium, it’s not so shocking that CBD has mood stabilizing effects.
“I believe that [ CBD ’s] anticonvulsant properties are actually inherently affecting the lability of probably the serotonin, probably of dopamine, and actually smoothing out the bipolar disorder patients into a more moderate range.”
But for Malka, CBD isn’t the end of the story. She feels it’s important to highlight how compounds within the cannabis plant hold multiple therapeutic keys for the complex bipolar symptoms that a multitude of pharmaceutical drugs fail to manage – without the horrendous side effects.
In Malka’s experience, terpenes play a key role in managing cycling episodes and she favors myrcene to promote calmness and improve sleep during manic phases and alpha pinene and/or limonene for invigorating patients when they fall into depression.
Caution With THC
She will turn to THC chemovars containing myrcene to regulate sleep, which is often disrupted in bipolar disorder, but does not recommend THC when patients are manic or experiencing suicidal ideations.
Bipolar patients should seek help from an experienced physician before trying cannabis to manage their mood fluctuations.
“If somebody uses too much stimulating THC -rich cannabis because that’s what you’d want to use if you’re suicidal and in a very low mood,” explains Malka, “it alters your perception to a place where you skip reasoning and you just get disoriented, especially if you’re not used to cannabis. Too much THC can actually induce a psychotic experience. So, we don’t want that.”
To avoid any worsening of symptoms, Malka recommends bipolar patients seek professional help from an experienced physician before trying cannabis to manage their mood fluctuations.
“It’s really not safe if you’re a naive patient,” she stresses. “Too much THC is not safe, especially when you have a mood disorder. Please don’t do that. Get professional help.”
Preliminary Clinical Studies
With the buzz surrounding the therapeutic application of CBD in a number of mood disorders, including as an antipsychotic treatment in schizophrenia, 13 it’s not a surprise that a preliminary clinical trial is examining whether the compound could also be effective in bipolar disorder. This despite some earlier reviews 14 finding only weak evidence that CBD was effective for BD . 15
So far, unfortunately, there are no definitive results to report. One small Brazilian study, 16 which was terminated prematurely due to COVID , gave 36 bipolar patients 150-300 mg of CBD or a placebo over twelve weeks, to assess whether their depression and anxiety symptoms improved, as well as measuring inflammatory biomarkers. However, despite ending the study early, the researchers have been able to submit the results to a journal, which is awaiting review and hopefully a future publication.
Another clinical trial 17 currently recruiting in San Diego, will compare the administration of a one-time 600mg dose of Epidiolex (pharmaceutical CBD ) with 5mg of dronabinol (synthetic THC ) and a placebo on 144 bipolar participants in order to assess their effects on “cognitive domains relevant to bipolar disorder, e.g., arousal, decision making, cognitive control, inhibition, and temporal perception (sense of timing),” as well as measuring anandamide, an endocannabinoid and homovanillic acid, a marker of dopamine activity in the brain.
However, the study’s objective appears to be less about cannabinoids as potential treatment for bipolar disorder and more geared towards understanding why many patients with BD also suffer from substance abuse.
It appears then that the stigma against cannabis and bipolar disorder among health professionals remains ingrained, and more clinical trials are needed before prescribing CBD -rich cannabis or just plain old CBD will be readily accepted by mental health clinicians and psychiatrists.
Mary Biles, a UK -based journalist, educator, and Project CBD contributing writer, is the author of The CBD Book (Harper Collins, UK ).
Copyright, Project CBD . May not be reprinted without permission.
CBD for Bipolar Disorder: Potential Treatment and Benefits
Communication between the neurotransmitters in your brain is a key player in mood stabilization. These chemical messengers help regulate your thoughts, feelings, mood, and behavior. But in order to function properly, they need to be balanced; otherwise, our brain will become either hyperactive or hypoactive. The frequent fluctuation between the activity of neurotransmitters may lead to a range of mood disorders, including bipolar disorder.
The driving force behind the functioning of neurotransmitters and their matching receptors is called the endocannabinoid system (ECS). The discovery of the ECS has given researchers new insight into the interaction between different chemicals in your body; what happens when the communication system fails; and how to potentially restore the neurochemical homeostasis.
Today we’ll cover the role of the endocannabinoid system in the development of the bipolar disorder, a pesky condition whose symptoms can negatively impact your daily life as well as people around you.
We’ll also explain how cannabidiol – CBD may contribute to healthy communication between neurotransmitters, thus reducing the severity of bipolar disorder.
Let’s jump right into this without further ado.
Bipolar Disorder and CBD
A 2010 study published in the journal Psychological Medicine suggested that cannabis can improve cognitive functioning in people with mental disorders. Interestingly, the study tested low doses of high-THC cannabis strains (marijuana) (1). And while people with bipolar disorders may benefit from small amounts of THC, using intoxicants — even in moderate amounts — is a controversial approach among the sufferers and medical professionals.
However, THC is only one of the 115 identified cannabinoids in the cannabis plant. The second major compound, CBD, is non-intoxicating and can actually counteract the psychoactive effects of THC. According to a 2015 study published in the Journal of Psychopharmacology, using CBD has the same antipsychotic and anticonvulsant properties as conventional bipolar disorder medications (2). Considering the lack of intoxicating effects, hemp-derived CBD oil will be a decent pick for bipolar sufferers.
CBD products sourced from hemp are more accessible due to the recent legal changes in hemp cultivation and sales. The US federal government legalized hemp under the 2018 Farm Bill, which was de-scheduled from the Controlled Substances Act. Hemp is now an agricultural commodity that can be grown for a variety of purposes. Hemp-derived CBD is widely available without a prescription; you can find it in local organic stores, dispensaries, vape shops, and online.
Here’s how CBD can help manage the symptoms of bipolar disorder.
CBD as a Mood Stabilizer
CBD is touted for its ability to reduce stress and anxiety. Numerous studies have mentioned the anxiolytic and antidepressant-like properties of CBD oil. People use CBD to manage different types of mental disorders, including panic disorder, general anxiety disorder, social anxiety, post-traumatic stress disorder (PTSD), schizophrenia, and more.
Below we share an explanation of the mechanisms behind CBD’s therapeutic effects.
CBD May Alleviate Manic Episode
People with bipolar disorder often show intense symptoms of mania, during which they feel highly motivated and filled with energy. In a 1998 study published in the Journal of Psychoactive Drugs, the authors concluded that cannabis users responded better to their herbal treatment than those given conventional medications. The study mentioned CBD as a promising treatment for bipolar disorder, although the results came from only one type of the condition — hypomania (3).
CBD Acts as a Natural Antidepressant
A 2007 study from the Journal of Neural Transmission correlated the depressive period of bipolar disorder with a low density of CB1 cannabinoid receptors in the brain. CBD may help restore these receptors through the endocannabinoid system signaling, which would explain its positive effects on bipolar disorder (4).
CBD also interacts with the serotonin receptors that regulate mood and emotional processing. CBD oil can enhance mood by helping the body use serotonin more effectively. With sufficient levels of serotonin in the circulatory system, and with CBD oil helping prevent anxiety and regulate sleep, bipolar patients may prevent depressive disorders.
CBD Improves Stress Response
Most anxiety-related disorders derive from stress, and CBD oil appears to be one of the most effective natural stress relievers known to mankind. Stressed people with a history of mental disorders in their families will only increase their risk of bipolar disorder if proper stress management is ignored.
Taking CBD oil daily for bipolar disorder can effectively support the endocannabinoid system, which is responsible for regulating stress responses among many other physiological functions.
People Don’t Get Addicted to CBD
Traditional bipolar medications, such as Symbiax, lithoid, and benzodiazepines like Xanax, Valium, and Klonopin are typically prescribed for bipolar disorder. However, they have a long list of possible adverse reactions, not to mention the negative consequences of their long-term use. In this clash, cannabis compounds have a much better safety profile.
Some of the common side effects of pharmaceutical medications include their addictive potential, difficulty sleeping, manic depression, weight gain, and suicidal ideation.
The only side effects of CBD oil you might experience are dry mouth, changes in appetite, drowsiness, fatigue, and diarrhea. However, in normal doses, these effects are almost non-existent. Studies on the side effects of CBD oil have concluded that the compound is safe in regular use. Unlike traditional medications, CBD is not addictive and can’t lead to a fatal overdose. In fact, CBD has been shown by recent research to relieve withdrawal symptoms and prevent relapse in those who have gone cold turkey (5).
The Role of Cannabinoid Neurotransmitters in Mood Stability
Your body produces the neurotransmitters called endocannabinoids — anandamide and 2-AG. These molecules interact with the endocannabinoid system, and their concentrations increase whenever the communication between the chemical messengers in your body gets disturbed. Your body also interacts with exogenous cannabinoids found in cannabis plants, such as hemp and marijuana. Both plants have their unique benefits, but marijuana has high levels of THC, which is an intoxicating compound. Hemp, on the other hand, comes with only 0.3% THC per dry mass, so using hemp-derived products like CBD oil won’t get you high.
Cannabinoids & Our Health
Plant-based cannabinoids mimic the effects of your endogenous cannabinoids, communicating with receptors in the ECS. The ECS is responsible for managing nearly every process and function in your body, including:
- Cardiovascular function
- Metabolism and energy
- Mood and emotional processing
- Neuroprotection and muscle movement
- Pain perception and inflammation
The endocannabinoids in your body are produced for a short duration and your body doesn’t store them. The exogenous cannabinoids are more potent, longer-lasting, and they can also signal the production of the endocannabinoids — allowing them to circulate longer in the bloodstream.
Long story short, cannabinoids from the cannabis plant help keep our master regulatory network in good shape in order to maintain well-being.
When this network falls out of whack, it may give rise to a range of health concerns. There’s even a medical term, the endocannabinoid deficiency, where the efficacy of ECS is compromised to the point it becomes deficient in its natural cannabinoids.
Research suggests that CBD has the potential to reduce pain, lower inflammation, bolster the immune system, improve sleep, and alleviate the symptoms of anxiety and depressive disorders, such as bipolar affective disorder. Studies of the endocannabinoid system are relatively new, but the results are promising.
Let’s make sure you’ve got a good understanding of bipolar disorder before we continue with the benefits of CBD for mental health.
Bipolar Disorder 101: Causes, Symptoms & Treatment Options
Bipolar disorder affects around 1.6 million Americans. It causes changes in a person’s mood, emotions, energy levels, behavior, and function. People with bipolar disorder experience extreme emotional states known as mood episodes. The complexity of the condition makes it easy to misdiagnose as depression.
The above episodes are broken down into manic, hypomanic, and depressive.
What Causes Bipolar Disorder?
Researchers have yet to find the underlying cause of the bipolar disorder, although the most likely explanation involves imbalances between specific neurotransmitters in the brain. As mentioned earlier, bipolar disorder is difficult to treat. People usually go through trial and error, most often trying one medication and waiting to see if it improves the symptoms. If not, another drug is prescribed until the symptoms become manageable.
Some of the causes of bipolar disorders include:
- Chronic depression
- Severe mental stress
- Hereditary factors (family history of bipolar disorder)
- Hormone imbalances
- Imbalances in neurotransmitters
- Post-traumatic stress disorder (PTSD)
Types of Bipolar Disorder & Their Symptoms
- Manic Episodes – a manic episode occurs when the receptors in the brain are overstimulated by the neurotransmitters. During a manic event, those with bipolar disorders experience a surge of energy, showing signs of being euphoric and highly motivated. The overexcitation may lead to a short attention span, recklessness, anxiety, and insomnia. Manic episodes may also cause paranoia, delusions, and psychosis.
- Hypomanic Episodes –During a hypomanic episode, a person goes through a less severe version of the manic episode, often being put between mania and depression. Those under the influence of a hypomanic episode struggle with anxiety and distractor, although they’re usually able to complete their daily tasks.
- Major Depressive Episodes – a major depressive episode involves the opposite symptoms of mania. It results in low motivation, feelings of sluggishness, low energy levels, and depression. This type of bipolar disorder is also accompanied by social isolation and suicidal thoughts.
How Is Bipolar Disorder Typically Treated?
Treating bipolar disorder is difficult because it is a multifaceted problem. The best approach to the problem is a combination of counseling and psychiatric care. Psychotherapy helps patients determine behavioral problems, such as high mental stress or a history of substance abuse. Other contributors, such as hormonal imbalances, should also be analyzed and treated pharmacologically.
Doctors usually prescribe the following medications for bipolar disorder:
- Mood stabilizers (carbamazepine, lithium, valproic acid)
- Antipsychotics (Abilify, Latuda, Zyprexa)
- Antidepressants (Sertraline)
- Antidepressant-antipsychotics (Symbyax)
- Anticonvulsants (Depakote, Tegretol)
However, these medications often have dangerous side effects. For this reason, people have started seeking help in complementary treatments, such as sensory deprivation, elimination of mental stresses, nutritional adjustments, support groups, herbal medicine, and CBD supplementation.
Below we share the current scientific findings regarding the use of CBD for bipolar disorder.
Pros & Cons of Using CBD Oil for Bipolar Disorder
- In vitro studies show that CBD is a neuroprotectant, including reduction of oxidative stress and free radical damage. These factors are believed to contribute to the development of the bipolar disorder (6).
- CBD promotes healthy stress responses. It can also alleviate both acute and chronic anxiety.
- CBD is an anti-inflammatory. Chronic inflammation may damage neurons in the brain, leading to imbalances in neurotransmitters. The anti-inflammatory effects of CBD have been found in both animal and human studies.
- CBD is non-intoxicating, so it won’t get you high. This is a particularly valuable trait, as intoxicants are known for increasing the risk of aggravating the symptoms of bipolar disorder.
- You can’t get addicted to CBD.
- CBD doesn’t have the serious side effects associated with commonly prescribed antipsychotics.
- The CBD market is largely unregulated, so there’s a risk of buying a mislabeled product that contains significant amounts of THC, even if the label states otherwise.
- Much of the evidence supporting the benefits of CBD for bipolar disorder comes from animal studies and preclinical human trials. More clinical studies are needed to determine whether the effects of CBD are consistent on large groups of the population.
How to Use CBD for Bipolar Disorder?
- CBD Oil – CBD oil is the most common form of cannabidiol due to its ease of use and dosage precision. CBD oil contains hemp extract and food-grade inert oil. The infusion in the carrier oil boosts the bioavailability of CBD, allowing lower doses to remain effective. Such a product is easier to apply and dose. CBD oil is taken under the tongue, where the user holds it for up to a minute before swallowing.
- CBD Capsules – Capsules are a good choice if you dislike the natural taste of CBD oil. They also take away the guesswork associated with dosing CBD in the liquid form because each capsule contains a premeasured dose. All you need to do is take as many capsules as you need to match your dosage and swallow them down with water. Since capsules need to pass through the digestive system, they have a delayed onset, usually kicking in after 40–90 minutes.
- CBD Edibles – Edibles like gummies and honey sticks provide a fun way to supplement CBD. The only concern when it comes to CBD edibles is the lower potency of the final dose. Similar to capsules, edibles need to be processed in your gut before they can be released into the bloodstream, so dosing is often inconsistent and unreliable.
- CBD Vape Pens – if you’re looking for the most efficient of all consumption methods in terms of dosing, then CBD vape pens will be your best bet. Vaporized CBD shows the highest bioavailability because it enters the bloodstream through the lungs. As a result, the CBD acts within minutes after inhalation. Vaping is a good choice for people with bipolar disorder because it provides consistent dosage and fast symptom relief.
How Often Should You Take CBD for Bipolar?
Consistency is an essential component of successful bipolar disorder treatment. Only by being consistent can you manage the symptoms of the condition and level the endocannabinoid deficiencies in your system, which is one of the probable causes of bipolar disorder.
For the best results, you should take CBD a few times a day depending on the route of administration. CBD oils provide relatively long-lasting effects, up to 6 hours, allowing the user to split the dosage into two servings. For products like CBD hemp flowers or CBD vapes, you’ll probably need to use them more often, as vaporized CBD has a shorter duration, usually between 3–4 hours.
How Much CBD to Take for Bipolar Disorder?
Finding the optimal dosage range for your situation will require some experimenting. Everybody is different, so a dose that works for your friend may not necessarily be enough to relieve your symptoms. Self-testing is an inevitable part of that process, but the goal is to minimize the number of errors.
Most experts recommend starting with a low dose and gradually increasing it until you find the desired relief from your bipolar disorder. Many bipolar patients experience benefits upon reaching a medium- or high-strength dose. The amount of CBD oil you’ll need to notice the positive change depends on the severity of your symptoms and your overall health. The only way to determine your effective dosage range is to try it out.
You can start by taking 10 mg twice a day — in the morning and in the evening — and observe the effects for one week. It’s good to keep a dosage journal where you will keep notes of how you feel after each dose, and whether or not it alleviates your symptoms. If you find no change after that time, add another 10 mg to your routine and continue the trial. Once you’ve reached the sweet spot, you can lock in at that dosage.
Is CBD Safe?
Taking CBD for bipolar disorder doesn’t carry a risk of life-threatening side effects. In fact, CBD has been mentioned by several studies as a safe and well tolerable compound. In humans, examined dosages ranged between 300–1,500 mg of CBD daily. However, there are a few mild reactions you should keep in mind when using CBD oil for bipolar disorder. Since most people with the condition benefit from medium- to high-strength doses, you may experience the following side effects:
- Dry mouth
- Changes in appetite
CBD-drug interactions are also possible, so we encourage you to visit a doctor knowledgeable about CBD and cannabis to avoid these interactions. A qualified professional will also help you establish the right dosage regime to maximize the benefits of your treatment.
CBD vs Lithium: Which is Better for Bipolar Treatment?
CBD is praised for its ability to stabilize mood and alleviate anxiety. Anecdotal reports, as well as clinical evidence, indicate that CBD produces the same effects as some other bipolar medication and antidepressants.
Like we said, CBD has remarkable antioxidant properties and neuroprotective effects which may help patients with bipolar disorder without causing dangerous adverse effects. There are also studies suggesting that CBD acts similarly to atypical and antipsychotic drugs, thereby producing mood-stabilizing and anticonvulsant effects.
Lithium is prescribed for treating certain types of depression, especially bipolar one. It’s effective and has been used for decades by psychiatrists. Despite its mood-stabilizing properties, scientists aren’t sure how these effects are exactly produced. Nevertheless, studies have proven that lithium-based medications can reduce the frequency of suicidal thoughts during manic episodes. These properties have been attributed to lithium’s interaction with a certain nervous system, increasing the number of neurotransmitters that help balance mood. Lithium also strengthens nerve connections, translating into a better regulation of emotions.
However, lithium also has dangerous side effects. Approximately 70% of bipolar patients treated with lithium experience negative reactions. Although most of them are minor, common side effects of taking lithium include acne, diarrhea, poor memory, and weight gain. High doses of lithium are associated with ringing ears, poor muscle control, and blurry vision. Hypothyroidism is another potential side effect of long-term lithium treatment. It can also give rise to rare but severe kidney illnesses. None of these side effects were observed during the studies examining the safety and efficacy of CBD.
Summarizing the use of CBD for Bipolar Disorder
Bipolar disorder can negatively impact your daily life. The condition is not only challenging to diagnose but also difficult to treat, often involving a series of trial-and-error with different pharmaceutical medications. Some of these drugs are simply ineffective, while others pose a threat to one’s health with long-term use.
People are now turning to natural remedies for bipolar disorder, one of them being CBD oil. Some studies suggest CBD can be a safe and effective alternative to conventional treatments. CBD indirectly affects different neurotransmitters and hormones, balancing their activity, and thus helping the body maintain its homeostasis, especially in the central nervous system. Researchers are wondering if CBD can address the probable underlying cause of bipolar disorder — the clinical endocannabinoid deficiency (CECD). Studies on animal models, as well as preclinical human trials, have shown promising results in this regard.
If you’re considering adding CBD oil as a complementary treatment for bipolar disorder, make sure to consult the idea with your doctor. You should also do your research on your potential vendors, as no two CBD oils are the same. The CBD market lacks regulation when it comes to manufacturing and labeling standards, and some brands are very liberal when it comes to health claims and the cannabinoid content of their products.
Did you try CBD oil for bipolar disorders? Share your thoughts in the comments!
- Ringen, P A et al. “Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.” Psychological medicine vol. 40,8 (2010): 1337-47. doi:10.1017/S0033291709991620
- Blessing, Esther M et al. “Cannabidiol as a Potential Treatment for Anxiety Disorders.” Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics vol. 12,4 (2015): 825-36. doi:10.1007/s13311-015-0387-1
- Grinspoon, L, and J B Bakalar. “The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research.” Journal of psychoactive drugs vol. 30,2 (1998): 171-7. doi:10.1080/02791072.1998.10399687
- Koethe, D et al. “Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression.” Journal of neural transmission (Vienna, Austria : 1996) vol. 114,8 (2007): 1055-63. doi:10.1007/s00702-007-0660-5
- Prud’homme, Mélissa et al. “Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence.” Substance abuse: research and treatment vol. 9 33-8. 21 May. 2015, doi:10.4137/SART.S25081
- Machado-Vieira, Rodrigo et al. “Oxidative stress parameters in unmedicated and treated bipolar subjects during an initial manic episode: a possible role for lithium antioxidant effects.” Neuroscience letters vol. 421,1 (2007): 33-6. doi:10.1016/j.neulet.2007.05.016
Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.
CBD for Bipolar Disorder: Does It Help?
Laura Dorwart is a health journalist with expertise in disability rights, mental health, and pregnancy-related conditions. She has written for publications like SELF, The New York Times, VICE, and The Guardian.
Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Erika Prouty, PharmD, is a professional community pharmacist who aids patients in medication management and pharmacy services in North Adams, Massachusetts.
Bipolar disorder refers to a group of mental health disorders that cause extreme highs and lows in mood. According to the National Institute of Mental Health (NIMS), 4.4% of adults in the United States experience bipolar disorder at some point in their lives.
A person with bipolar disorder, previously known as manic depression, experiences disruptive mood fluctuations that interfere with their daily functioning in relationships, work, school, and family life. These mood fluctuations usually include both “high highs,” such as mania and hypomania, and “low lows” in the form of depressive episodes.
Cannabidiol, or CBD, has been touted as a possible way of treating the symptoms of bipolar disorder. While there’s some evidence that CBD oil can help people with bipolar disorder, there hasn’t been enough research to establish its long-term safety and effectiveness.
Learn more about CBD for bipolar disorder, including its safety, effectiveness, drawbacks, and alternatives.
Catherine Falls Commercial / Moment / Getty Images
What Is CBD?
CBD is one of the active ingredients in the Cannabis sativa plant (marijuana). Although it’s a chemical derived from marijuana, CBD doesn’t have psychoactive properties like tetrahydrocannabinol (THC). In other words, CBD won’t get you “high” like THC.
CBD is believed to act on the body’s central nervous system to produce a calming, relaxing effect that could help with anxiety and other mental health conditions, such as bipolar disorder. Some evidence suggests that it also might have pain-relieving and anti-inflammatory properties.
Is CBD Addictive?
According to the World Health Organization (WHO), there’s no evidence of any risk of chemical dependency or addiction when it comes to CBD.
And while CBD’s legal restrictions vary from state to state, the Food and Drug Administration (FDA) has legalized its use for clinical trials. One product containing CBD—Epidiolex—was FDA approved in 2018 for use in the treatment of seizures in certain rare childhood epileptic disorders.
You can take CBD in various forms, including:
- Tinctures (plant extracts dissolved in an alcohol solvent)
- Tablets and capsules
- Edibles, such as gummies
- Topicals, such as lotions and creams
Because CBD’s legal status varies so widely across the United States, it’s always wise to check your local and state laws before purchasing any product containing CBD.
The Science Behind CBD
CBD oil isn’t yet established as an evidence-based treatment for bipolar disorder. Research is ongoing, with many clinical trials underway.
However, it’s believed that CBD works by acting on the body’s endocannabinoid system (ECS). The endocannabinoid system isn’t yet entirely understood by researchers, but some believe it plays a role in many important functions, such as pain and mood regulation as well as inflammation.
Early research indicates that CBD might serve as a mood stabilizer for people with bipolar disorder.
One 2020 review argues that CBD might be helpful in the treatment of depressive episodes associated with bipolar disorder due to its calming, antidepressant effects.
A 2020 clinical trial suggests that CBD could be beneficial as an “adjunctive,” or supplemental, treatment for bipolar depression.
CBD has also been shown to have an anxiety-reducing effect and shows therapeutic potential in the treatment of addictions. This could be beneficial to people with bipolar disorder because many people with mood disorders also have comorbid mental health conditions, such as anxiety disorders and substance use disorder.
CBD and Its Potential Benefits
CBD is being investigated for use in the treatment of a number of mental health disorders and neurological conditions. These include schizophrenia, post-traumatic stress disorder (PTSD), anxiety disorders, depression, addiction, and Alzheimer’s disease.
There are certain drawbacks to taking CBD for bipolar disorder. People who use CBD products might experience a range of side effects, including:
CBD can also interact with other medications, such as blood thinners, and it can affect your liver enzymes.
If you take CBD, it’s important to let your healthcare provider know so they can warn you about any potential drug interactions or negative effects on your liver function. You also shouldn’t drink alcohol if you’re using CBD, as the interaction between the two substances could enhance their sedative effects.
There’s limited evidence in initial animal studies that the male reproductive system could be affected by CBD use. So if you’re trying to conceive, you might want to hold off on using CBD or ask your healthcare provider if CBD is safe to use.
Also, most products containing CBD aren’t regulated or approved by the FDA. This means that you can’t guarantee that what you buy is safe, pure, or high-quality. A CBD product could contain THC or even contaminants like pesticides, so choose carefully.
There are many evidence-based alternatives to using CBD for bipolar disorder symptoms. Here are some of the many available alternative treatments for bipolar disorder:
- Medication: There are a number of prescription medications available to treat the symptoms of bipolar disorder. Mood stabilizers such as lithium, as well as anticonvulsants and antipsychotic drugs, may be prescribed by a psychiatrist to help regulate your moods.
- Psychotherapy:Talk therapy with a trusted psychotherapist, as well as support groups led by qualified mental health counselors, can help you work through the emotional and social challenges of living with bipolar disorder.
- Exercise: Regular exercise can help people with bipolar disorder by releasing endorphins that improve their sense of well-being.
- Relaxation and mindfulness techniques: Relaxation techniques such as breathing exercises, and mindfulness techniques such as yoga and meditation, can have a calming effect and help you regulate your emotions in times of stress.
- Sleep hygiene:Insomnia and chronic sleep deprivation can worsen the effects of bipolar disorder. Practicing good sleep habits, such as going to bed at the same time every night, can go a long way in curbing bipolar disorder symptoms.
Some researchers believe that CBD, a chemical compound derived from marijuana, could be helpful in treating some of the symptoms of bipolar disorder and other mental health conditions.
Early evidence suggests that CBD oil could play a role in regulating mood and alleviating depression. Drawbacks can include mild to moderate side effects like nausea and fatigue, as well as potential drug interactions and negative effects on liver function.
Alternative treatments for bipolar disorder include prescription drugs, psychotherapy, mindfulness techniques, and lifestyle changes.
A Word From Verywell
CBD is widely believed to be safe and potentially effective in the treatment of various mental health conditions, including bipolar disorder. However, it’s not FDA approved as a treatment for bipolar disorder, and research into its benefits and long-term side effects is still ongoing.
If you decide to take CBD for bipolar disorder, make sure to let your healthcare provider know so they can warn you about any potential side effects or drug interactions.
Frequently Asked Questions
Research on CBD and its potential interactions with other drugs is ongoing. There is some preliminary evidence that CBD could interact with lithium, which is frequently prescribed to people with bipolar disorder as a mood stabilizer. This interaction could potentially cause lithium toxicity, a serious condition.
CBD, or cannabidiol, is one of the chemical compounds (called “cannabinoids”) found in the Cannabis sativa plant. Cannabis also contains tetrahydrocannabinol (THC), the main active component of marijuana. Unlike THC, CBD doesn’t have psychoactive properties; in other words, it won’t give you a “high.”
The only FDA-approved product containing CBD is a pharmaceutical-grade CBD oil called Epidiolex, which is used to prevent seizures in people with two different childhood epileptic disorders. Because most CBD products aren’t regulated by the FDA, it’s important to check the product labels yourself.
Always check your CBD product’s certificate of analysis (COA) to see if it’s been tested for THC and contaminants. Also, CBD derived from hemp grown in the U.S. rather than overseas might be a safer bet in terms of the federal and local testing requirements.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
National Institute of Mental Health. Bipolar disorder.
Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics. 2015;12(4):825-836. doi:10.1007/s13311-015-0387-1
Khan R, Naveed S, Mian N, et al. The therapeutic role of cannabidiol in mental health: a systematic review. J Cannabis Res. 2020;2(2). doi:10.1186/s4438-019-0012-y
Oberbarnscheidt T, Miller NS. The impact of cannabidiol on psychiatric and medical conditions. J Clin Med Res. 2020;12(7):393-403. doi:10.14740/jocmr4159
Singh RK, Dillon B, Tatum DA, et al. Drug-drug interactions between cannabidiol and lithium. Child Neurol Open. 2020;7. doi:10.1177/2329048X20947896
By Laura Dorwart
Laura Dorwart is a health journalist with particular interests in mental health, pregnancy-related conditions, and disability rights. She has published work in VICE, SELF, The New York Times, The Guardian, The Week, HuffPost, BuzzFeed Reader, Catapult, Pacific Standard, Health.com, Insider, Forbes.com, TalkPoverty, and many other outlets.