Tell your rheumatologist and anyone else who prescribes medication for you. If you need surgery, an anesthesiologist may choose a different dose or type of anesthesia if you’re using CBD.
Rheumatologists are always on the alert for liver problems that may result from arthritis medications, and that includes CBD as well as NSAIDs and methotrexate.
“Based on what we know now about the way CBD is metabolized, I would not expect significant drug-drug interactions with drugs commonly used in arthritis treatment, such as methotrexate, and most nonsteroidal anti-inflammatory drugs (NSAIDs). I would advise caution on one NSAID, diclofenac, because there isn’t information on how CBD affects — if at all — the enzyme that metabolizes it,” says Dr. Bemben.
A huge number of medications, including CBD, are broken down by the same large family of liver enzymes, called CYP450.
Which health professionals need to know I’m trying CBD?
“While patients may be wary of stigma surrounding CBD products, I believe most health care providers understand this is a growing area and one strategy patients are trying in hopes of getting relief,” she says.
CBD inhibits some enzymes in this family. This makes them break down certain drugs more slowly, which could potentially increase side effects unless your doctor adjusts the dose. On the other hand, CBD induces other enzymes in this family, which speeds the breakdown of certain drugs so they may potentially be less effective unless the dose is increased.
Dr. Patel worries in particular about any side effects or interactions that result in dizziness and may increase the risk of falls in the elderly. For example, using the antidepressant fluoxetine together with cannabis products can increase dizziness and drowsiness.
Are older people more at risk of CBD drug interactions?
One source available to patients is drugs.com, where you can plug in either cannabidiol (which will give you the FDA-approved oral product Epidiolex) or cannabis (which will give you both THC and CBD) and check for possible interactions with other medications you take.
We put commonly asked questions to Nina M. Bemben, PharmD, BCPS, a specialist in drug interactions who is trying to educate other pharmacists about possible drug-drug interactions with CBD, as well as Rachna Patel, DO, a physician who does consultations about medical marijuana and CBD and sells her own line of CBD products.
In Canada , about 11% of men and 16% of women will experience major depression over the course of their lives. However, the growing awareness of mental health issues and the advancement of both medication and natural treatments means that, for many people, depression can be treated effectively.
CBD is safe for most people, with little to no side effects, unlike SSRIs. CBD can also work to almost instantly treat symptoms caused by depression, whereas it may take weeks for someone to feel the effects of antidepressants.
Selective Serotonin Reuptake Inhibitors (SSRIs), better known as antidepressant medications, work to increase the activity of certain neurotransmitters in the brain. Serotonin, norepinephrine, and dopamine are chemicals in the brain that impact mood and feelings of well-being. SSRIs help to increase the activity of these specific neurotransmitters, thereby decreasing symptoms of depression and anxiety.
Can CBD oil and antidepressants work to treat depression?
Full spectrum CBD is a whole plant extract that contains CBD and all 100+ other cannabinoids, amino acids, and essential oils found within the plant. These compounds all have various benefits and work together in what is known as the “entourage effect” to increase efficacy. For this reason, full spectrum CBD is often considered the best type of extraction and is typically priced higher.
Isolate CBD is 99% pure CBD. In isolate CBD, the whole plant extract has been further refined to isolate the CBD compound, thereby removing all other cannabinoids, essential oils, and amino acids. While this is the purest form of CBD, it does not deliver the so-called “entourage effect”.
Is it safe to take CBD oil and SSRI antidepressants?
For those with depression, neurons are formed slowly, which can lead to feelings of anxiousness or even suicidal thoughts . According to another study , a single dose of CBD oil helped increase blood flow to the hippocampus, which shows promise in treating symptoms of psychosis, depression, memory disorders, and anxiety.
While more scientific research is needed to see how CBD oil and SSRIs can work together, medical experts say it is safe for CBD oil and SSRIs to be taken together.
There’s no denying that CBD, aka cannabidiol, has been the reigning trend of the last few years, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic, and safe way to manage a variety of health issues, you may be wondering if you can take CBD and antidepressants together. And while CBD is touted as an all-natural supplement with some evidence that it can be good for your health, it’s possible that your CBD latte can still impact the efficacy of different medications — including antidepressants.
What’s more, Grinspoon says that CBD also inhibits “the system that metabolizes a lot of serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and antipsychotics as well.” Meaning, taking CBD supplements while on these psychiatric medications could hypothetically interfere with how these medications are metabolized.
“Generally speaking, you can safely use CBD supplements when you’re taking antidepressants. However, there are a couple of concerns,” Dr. Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction, tells Bustle. “The first concern is that CBD isn’t regulated by the FDA. You have to be careful that the CBD you’re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because they’ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.” (THC is the cannabis compound that, unlike CBD, can get you high.)