Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
Doubling up on side effects
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
CBD can alter the effects of other drugs
Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included
The safety profile of CBD is well-established, with extensive clinical research showing that it’s safe and well-tolerated while rarely producing any serious side effects.
CBD interacts with the endocannabinoid system (ECS), which is located throughout the body. It regulates numerous aspects of homeostasis (balance) — including temperature regulation, pain transmission, hormone levels, nerve transmission, satiety, and more.
Is It Safe to Take CBD & Quetiapine (Seroquel) Together?
Quetiapine (Seroquel) and CBD can be effective in treating schizophrenia, mood disorders, and other mental health conditions. However, as the same enzyme metabolizes these two medicines, these can interact easily, leading to adverse effects.
Is CBD a Viable Alternative to Quetiapine (Seroquel)?
CBD and quetiapine (Seroquel) are metabolized by the same sets of these enzymes (mainly CYP3A4).